U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H27N5O4S
Molecular Weight 445.535
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLIPIZIDE

SMILES

CC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

InChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

HIDE SMILES / InChI

Molecular Formula C21H27N5O4S
Molecular Weight 445.535
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/glipizide.html

Glipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans glipizide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glipizide. Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Glipizide is used as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory. Glipizide is marketed by Pfizer under the brand name Glucotrol in the USA, where Pfizer sells Glucotrol in doses of 5 and 10 milligrams and Glucotrol XL (an extended release form of glipizide) in doses of 2.5, 5, and 10 milligrams. Other companies also market glipizide, most commonly extended release tablets of 5 and 10 milligrams.

Originator

Curator's Comment: first described by Ambrogi in 1971

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
GLUCOTROL

Approved Use

GLUCOTROL is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Launch Date

1984
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
523 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
465 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1897 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
1878 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.65 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
3 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLIPIZIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
1.5%
GLIPIZIDE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
375 mg single, oral
Overdose
Dose: 375 mg
Route: oral
Route: single
Dose: 375 mg
Co-administed with::
melformin, p.o(14.5 g; single)
Sources: Page: p.565
healthy, 15
n = 1
Health Status: healthy
Age Group: 15
Sex: F
Population Size: 1
Sources: Page: p.565
Disc. AE: Hypoglycaemia...
AEs leading to
discontinuation/dose reduction:
Hypoglycaemia
Sources: Page: p.565
1 g single, oral
Overdose
Dose: 1 g
Route: oral
Route: single
Dose: 1 g
Co-administed with::
insulin, i.v(1600 u; single)
Sources: Page: p.265
unhealthy, 55
n = 1
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: 55
Sex: M
Population Size: 1
Sources: Page: p.265
Disc. AE: Hypoglycaemic encephalopathy...
AEs leading to
discontinuation/dose reduction:
Hypoglycaemic encephalopathy (grade 5)
Sources: Page: p.265
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(>/=1500 mg/day; 52 wk)
Sources: Page: p.199
unhealthy, 56.6 (9.8)
n = 584
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: 56.6 (9.8)
Sex: M+F
Population Size: 584
Sources: Page: p.199
Disc. AE: Myocardial infarction, Abortion spontaneous...
AEs leading to
discontinuation/dose reduction:
Myocardial infarction (serious, 0.17%)
Abortion spontaneous (serious, 0.17%)
Sources: Page: p.199
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(1500–2500mg/day)
Sources: Page: p.2020
unhealthy, >/=18 years
n = 408
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: >/=18 years
Sex: M+F
Population Size: 408
Sources: Page: p.2020
Disc. AE: Hypoglycemia, Pyelonephritis...
AEs leading to
discontinuation/dose reduction:
Hypoglycemia (0.7%)
Pyelonephritis (0.25%)
Sources: Page: p.2020
40 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: p.3
unhealthy
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Sources: Page: p.3
Disc. AE: Cardiovascular disorder NOS...
AEs leading to
discontinuation/dose reduction:
Cardiovascular disorder NOS (grade 5)
Sources: Page: p.3
AEs

AEs

AESignificanceDosePopulation
Hypoglycaemia Disc. AE
375 mg single, oral
Overdose
Dose: 375 mg
Route: oral
Route: single
Dose: 375 mg
Co-administed with::
melformin, p.o(14.5 g; single)
Sources: Page: p.565
healthy, 15
n = 1
Health Status: healthy
Age Group: 15
Sex: F
Population Size: 1
Sources: Page: p.565
Hypoglycaemic encephalopathy grade 5
Disc. AE
1 g single, oral
Overdose
Dose: 1 g
Route: oral
Route: single
Dose: 1 g
Co-administed with::
insulin, i.v(1600 u; single)
Sources: Page: p.265
unhealthy, 55
n = 1
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: 55
Sex: M
Population Size: 1
Sources: Page: p.265
Abortion spontaneous serious, 0.17%
Disc. AE
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(>/=1500 mg/day; 52 wk)
Sources: Page: p.199
unhealthy, 56.6 (9.8)
n = 584
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: 56.6 (9.8)
Sex: M+F
Population Size: 584
Sources: Page: p.199
Myocardial infarction serious, 0.17%
Disc. AE
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(>/=1500 mg/day; 52 wk)
Sources: Page: p.199
unhealthy, 56.6 (9.8)
n = 584
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: 56.6 (9.8)
Sex: M+F
Population Size: 584
Sources: Page: p.199
Pyelonephritis 0.25%
Disc. AE
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(1500–2500mg/day)
Sources: Page: p.2020
unhealthy, >/=18 years
n = 408
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: >/=18 years
Sex: M+F
Population Size: 408
Sources: Page: p.2020
Hypoglycemia 0.7%
Disc. AE
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Co-administed with::
melformin, p.o(1500–2500mg/day)
Sources: Page: p.2020
unhealthy, >/=18 years
n = 408
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Age Group: >/=18 years
Sex: M+F
Population Size: 408
Sources: Page: p.2020
Cardiovascular disorder NOS grade 5
Disc. AE
40 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 40 mg, 1 times / day
Route: oral
Route: multiple
Dose: 40 mg, 1 times / day
Sources: Page: p.3
unhealthy
Health Status: unhealthy
Condition: Type 2 diabetes mellitus
Sources: Page: p.3
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
no (pharmacogenomic study)
Comment: there were detectable differences between CYP2C19 EMs and PMs in the pharmacokinetics and pharmacodynamics of glipizide, but none of these differences were statistically significant
yes
weak (co-administration study)
Comment: rifampin decreased the AUC(0-infinity) of glipizide by 22% (P <.05) and shortened its half-life from 3.0 to 1.9 hours (P =.01); pharmacogenomic studies also performed: CYP2C9 polymorphism significantly influences the pharmacokinetics and pharmacodynamics of glipizide, which needs to be considered in clinical practice
PubMed

PubMed

TitleDatePubMed
The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.
1999 Apr
Repaglinide: a review of its therapeutic use in type 2 diabetes mellitus.
2001
Decreased responsiveness of gluconeogenesis to the modulation by sulfonylureas in hepatocytes isolated from obese (fa/fa) Zucker rats.
2001 Feb 23
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
2001 Jan 19
Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide.
2001 Jun
Protein binding of glipizide using equilibrium dialysis technique: effects of hydrogen ion concentration, drug concentration and ionic strength.
2001 Mar
Preliminary evaluation of glipizide spheres and compacts from spheres prepared by cross-linking technique.
2001 Mar
Effects of sibutramine in obese female subjects with type 2 diabetes and poor blood glucose control.
2001 Nov
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
2001 Sep
Evaluation of Glyde File Prep in combination with sodium hypochlorite as a root canal irrigant.
2002 Apr
Metaglip and Avandamet for type 2 diabetes.
2002 Dec 23
Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice.
2002 Jan
Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.
2002 Jan-Feb
Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle.
2002 Mar
Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans.
2002 Oct
[Study of drug prescribing in patients older than 65 in Languedoc-Roussillon].
2002 Sep
Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: a technical note.
2003
Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents.
2003
[Oral antidiabetic therapy and cardiovascular complications: theoretical problem or clinical evidence?].
2003 Apr 6
Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin.
2003 Dec
Diabetes medicine update. Old dogs, new tricks.
2003 Jan-Feb
Modification of cardiovascular response of posterior hypothalamic adenosine A(2) receptor stimulation by adenylate cylase, guanylate cyclase and by K(ATP) channel blockade in anesthetized rats.
2003 Jun 19
Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failure.
2003 May
Improvements in glycemic control in type 2 diabetes patients switched from sulfonylurea coadministered with metformin to glyburide-metformin tablets.
2003 May-Jun
Effects of rosiglitazone maleate when added to a sulfonylurea regimen in patients with type 2 diabetes mellitus and mild to moderate renal impairment: a post hoc analysis.
2003 Nov
Targeting postprandial hyperglycemia: a comparative study of insulinotropic agents in type 2 diabetes.
2003 Nov
Risk of hypoglycaemia with oral antidiabetic agents in patients with Type 2 diabetes.
2003 Oct
Weight uniformity of split tablets required by a Veterans Affairs policy.
2003 Sep-Oct
Beneficial metabolic effects of chronic glipizide in obese African Americans with impaired glucose tolerance: implications for primary prevention of type 2 diabetes.
2004 Apr
Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: brief overview.
2004 Dec
Idiosyncratic toxicity associated with potentiated sulfonamides in the dog.
2004 Jun
Basal nitric oxide production contributes to membrane potential and vasotone regulation of guinea pig in vitro spiral modiolar artery.
2004 Mar
Simultaneous determination of glipizide and rosiglitazone unbound drug concentrations in plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry.
2004 Mar 5
Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride.
2004 May
Development and evaluation of osmotically controlled oral drug delivery system of glipizide.
2004 May
Tempol augments angiotensin II-induced AT2 receptor-mediated relaxation in diabetic rat thoracic aorta.
2004 Nov
The association of patient trust and self-care among patients with diabetes mellitus.
2004 Nov 16
Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry.
2004 Nov 5
Emphysematous cystitis: an unusual disease of the Genito-Urinary system suspected on imaging.
2004 Oct 5
Patents

Sample Use Guides

Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg
Route of Administration: Oral
Glipizide (100 uM) increased PPARγ transcriptional activity in Cos7 cells
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:22:48 GMT 2023
Edited
by admin
on Fri Dec 15 15:22:48 GMT 2023
Record UNII
X7WDT95N5C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLIPIZIDE
EP   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
1-CYCLOHEXYL-3-((P-(2-(5-METHYLPYRAZINECARBOXAMIDO)ETHYL)PHENYL)SULFONYL)UREA
Common Name English
GLIPIZIDE [USP MONOGRAPH]
Common Name English
GLIPIZIDE [JAN]
Common Name English
GLIPIZIDE COMPONENT OF METAGLIP
Common Name English
GLIPIZIDE [USAN]
Common Name English
METAGLIP COMPONENT GLIPIZIDE
Common Name English
GLIPIZIDE [VANDF]
Common Name English
K-4024
Code English
K 4024
Code English
GLIPIZIDE [USP-RS]
Common Name English
GLUCOTROL
Brand Name English
CP-28720
Code English
GLIPIZIDE SLOW RELEASE
Common Name English
GLIPIZIDE [EP MONOGRAPH]
Common Name English
GLIPIZIDE [MART.]
Common Name English
Glipizide [WHO-DD]
Common Name English
glipizide [INN]
Common Name English
GLIPIZIDE [ORANGE BOOK]
Common Name English
PYRAZINECARBOXAMIDE, N-(2-(4-((((CYCLOHEXYLAMINO)CARBONYL)AMINO)SULFONYL)PHENYL)ETHYL)-5-METHYL-
Systematic Name English
GLIPIZIDE [MI]
Common Name English
NSC-759120
Code English
CP-28,720
Code English
Classification Tree Code System Code
LIVERTOX 460
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
WHO-VATC QA10BB07
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
WHO-ATC A10BB07
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
NDF-RT N0000175608
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
NDF-RT N0000008054
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
NCI_THESAURUS C97936
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
Code System Code Type Description
CAS
29094-61-9
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
RS_ITEM_NUM
1292507
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PRIMARY
PUBCHEM
3478
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PRIMARY
CHEBI
5384
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PRIMARY
FDA UNII
X7WDT95N5C
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PRIMARY
NCI_THESAURUS
C29074
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PRIMARY
DAILYMED
X7WDT95N5C
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
ChEMBL
CHEMBL1073
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PRIMARY
DRUG BANK
DB01067
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PRIMARY
DRUG CENTRAL
1301
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PRIMARY
NSC
759120
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PRIMARY
MERCK INDEX
m5747
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PRIMARY Merck Index
INN
3090
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PRIMARY
MESH
D005913
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PRIMARY
IUPHAR
6821
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PRIMARY
WIKIPEDIA
Glipizide
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
RXCUI
4821
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PRIMARY RxNorm
ECHA (EC/EINECS)
249-427-6
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PRIMARY
EVMPD
SUB07927MIG
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
SMS_ID
100000090337
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
LACTMED
Glipizide
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID0040676
Created by admin on Fri Dec 15 15:22:48 GMT 2023 , Edited by admin on Fri Dec 15 15:22:48 GMT 2023
PRIMARY
Related Record Type Details
BINDER->LIGAND
BINDING
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
TARGET -> INHIBITOR
Sulfonylureas bind to and close ATP-sensitive K+ (KATP) channels on the cell membrane of pancreatic beta cells, which depolarizes the cell by preventing potassium from exiting. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of mature insulin.
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Related Record Type Details
METABOLITE LESS ACTIVE -> PARENT
METABOLITE LESS ACTIVE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.3
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.1
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC