ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8

Approval Year

Substance Class	Protein Created by `admin` on `Thu Jul 06 20:34:52 UTC 2023` Edited by `admin` on `Thu Jul 06 20:34:52 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	8RT5G5EY5Z
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8

Common Name

English

ABCC8

Common Name

English

SULFONYLUREA RECEPTOR 1

Common Name

English

SUR-1

Common Name

English

Code System Code Type Description

FDA UNII

8RT5G5EY5Z

Created by admin on Thu Jul 06 20:34:54 UTC 2023 , Edited by admin on Thu Jul 06 20:34:54 UTC 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_10
N	1_1049

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NATEGLINIDE

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GLYBURIDE

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Comments:

Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels decrease the K+ permeability of the cell membrane which leads to a depolarization of the cell, an enhanced Ca 2+ influx and the release of insulin

Amount:


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GLIMEPIRIDE

INHIBITOR -> TARGET

Comments:

An ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.