ONGERICIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:17:54 GMT 2025` Edited by `admin` on `Wed Apr 02 06:17:54 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	X126G5DZ36
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ongericimab [INN]

Preferred Name

English

ONGERICIMAB

Official Name

English

IMMUNOGLOBULIN G4, ANTI-(NEURAL APOPTOSIS-REGULATED CONVERTASE 1) (HUMAN MONOCLONAL JS002 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JS002 .KAPPA.-CHAIN, DIMER

Common Name

English

JS 002

Code

English

JS002

Common Name

English

JS-002

Code

English

Ongericimab [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENSPCSK9 (PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC1, NARC-1, PROPROTEIN CONVERTASE 9, PC9)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

Code System Code Type Description

INN

11188

Created by admin on Wed Apr 02 06:17:54 GMT 2025 , Edited by admin on Wed Apr 02 06:17:54 GMT 2025

PRIMARY

SMS_ID

300000024170

Created by admin on Wed Apr 02 06:17:54 GMT 2025 , Edited by admin on Wed Apr 02 06:17:54 GMT 2025

PRIMARY

FDA UNII

X126G5DZ36

Created by admin on Wed Apr 02 06:17:54 GMT 2025 , Edited by admin on Wed Apr 02 06:17:54 GMT 2025

PRIMARY

CAS

2145096-91-7

Created by admin on Wed Apr 02 06:17:54 GMT 2025 , Edited by admin on Wed Apr 02 06:17:54 GMT 2025

PRIMARY

NCI_THESAURUS

C174940

Created by admin on Wed Apr 02 06:17:54 GMT 2025 , Edited by admin on Wed Apr 02 06:17:54 GMT 2025

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From	To
1_22	1_95
2_22	2_95
2_125	4_213
2_138	2_194
2_252	2_312
1_125	3_213
2_358	2_416
3_23	3_88
3_133	3_193
4_23	4_88
4_133	4_193
1_138	1_194
1_217	2_217
1_220	2_220
1_252	1_312
1_358	1_416

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_288
N	2_288

Related Record Type Details


					LGW95S5DG1

PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9

TARGET->LIGAND

Related Record Type Details


					X126G5DZ36

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_438] [2_438]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL