CYCLOPENTHIAZIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H18ClN3O4S2
Molecular Weight	379.883
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NC(CC3CCCC3)NS(=O)(=O)C2=C1

InChI

InChIKey=BKYKPTRYDKTTJY-UHFFFAOYSA-N

InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

HIDE SMILES / InChI

Molecular Formula	C13H18ClN3O4S2
Molecular Weight	379.883
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/chlorothiazide

Cyclopenthiazide is a thiazide diuretic. It inhibits the Na+-Cl− symporter in the distal convoluted tubule of the kidney. Cyclopenthiazide is used for the treatment of edema, including that associated with heart failure, and for the treatment of hypertension.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Solute carrier family 12 member 3 3 Target ID: P55017 Gene ID: 6559.0 Gene Symbol: SLC12A3 Target Organism: Homo sapiens (Human) Sources: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/chlorothiazide	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Hypertension 575 Sources: https://imedi.co.uk/navidrex-0-5mg-tablets	Primary	Approved 8583	NAVIDREX Approved Use Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.
Edema 23 Sources: https://imedi.co.uk/navidrex-0-5mg-tablets	Primary	Approved 8583	NAVIDREX Approved Use Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.
Heart failure 106 Sources: https://imedi.co.uk/navidrex-0-5mg-tablets	Primary	Approved 8583	NAVIDREX Approved Use Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.

Doses

Dose	Population	Adverse events
500 ug 1 times / day multiple, oral Highest studied dose Dose: 500 ug, 1 times / day Route: oral Route: multiple Dose: 500 ug, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/3044503/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/3044503/	Sources: https://pubmed.ncbi.nlm.nih.gov/3044503/

PubMed

Title	Date	PubMed
Enalapril-related cholestatic jaundice.	1990-04	2342045
Is nifedipine a suitable first-line treatment for essential hypertension in general practice?	1987-11	3330028
Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.	1987-04	3297616
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.	1985-09	4041299
Effect of long-term diuretic treatment on body-potassium in heart-disease.	1976-11-13	62899
Letter: Paradoxical effect of pindolol.	1975-07-19	1139266

Sample Use Guides

In Vivo Use Guide

The usual adult dose is half of one tablet (0.25 mg) , or one whole tablet (0.5 mg) a day, alone or with other medicines.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:44 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:44 GMT 2025`
Record UNII	VX4S2N85F5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCLOPENTHIAZIDE

Official Name

English

NAVIDREX

Preferred Name

English

CYCLOPENTHIAZIDE [MI]

Common Name

English

cyclopenthiazide [INN]

Common Name

English

6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Systematic Name

English

CYCLOPENTHIAZIDE [JAN]

Common Name

English

SU-8341

Code

English

CYCLOPENTHIAZIDE [USAN]

Common Name

English

NSC-107679

Code

English

Cyclopenthiazide [WHO-DD]

Common Name

English

CYCLOPENTHIAZIDE [MART.]

Common Name

English

2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3-(CYCLOPENTYLMETHYL)-3,4-DIHYDRO-, 1,1-DIOXIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C49185