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Details

Stereochemistry UNKNOWN
Molecular Formula C13H18ClN3O4S2
Molecular Weight 379.883
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYCLOPENTHIAZIDE, (+)-

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NC(CC3CCCC3)NS(=O)(=O)C2=C1

InChI

InChIKey=BKYKPTRYDKTTJY-UHFFFAOYSA-N
InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

HIDE SMILES / InChI

Molecular Formula C13H18ClN3O4S2
Molecular Weight 379.883
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Cyclopenthiazide is a thiazide diuretic. It inhibits the Na+-Cl− symporter in the distal convoluted tubule of the kidney. Cyclopenthiazide is used for the treatment of edema, including that associated with heart failure, and for the treatment of hypertension.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P55017
Gene ID: 6559.0
Gene Symbol: SLC12A3
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NAVIDREX

Approved Use

Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.
Primary
NAVIDREX

Approved Use

Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.
Primary
NAVIDREX

Approved Use

Navidrex® 0.5mg Tablets are used to treat high blood pressure and some types of heart problems. They are also used to help reduce fluid retention associated with the pre-menstrual syndrome and some kidney or liver diseases.
Doses

Doses

DosePopulationAdverse events​
500 ug 1 times / day multiple, oral
Highest studied dose
Dose: 500 ug, 1 times / day
Route: oral
Route: multiple
Dose: 500 ug, 1 times / day
Sources:
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
PubMed

PubMed

TitleDatePubMed
Enalapril-related cholestatic jaundice.
1990-04
Is nifedipine a suitable first-line treatment for essential hypertension in general practice?
1987-11
Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.
1987-04
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
1985-09
Effect of long-term diuretic treatment on body-potassium in heart-disease.
1976-11-13
Letter: Paradoxical effect of pindolol.
1975-07-19

Sample Use Guides

In Vivo Use Guide
The usual adult dose is half of one tablet (0.25 mg) , or one whole tablet (0.5 mg) a day, alone or with other medicines.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Apr 02 19:47:42 GMT 2025
Edited
by admin
on Wed Apr 02 19:47:42 GMT 2025
Record UNII
T7817XC41U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
(+)-CYCLOPENTHIAZIDE
Preferred Name English
CYCLOPENTHIAZIDE, (+)-
Common Name English
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3-(CYCLOPENTYLMETHYL)-3,4-DIHYDRO-, 1,1-DIOXIDE, (+)-
Systematic Name English
Code System Code Type Description
CAS
96783-05-0
Created by admin on Wed Apr 02 19:47:42 GMT 2025 , Edited by admin on Wed Apr 02 19:47:42 GMT 2025
PRIMARY
FDA UNII
T7817XC41U
Created by admin on Wed Apr 02 19:47:42 GMT 2025 , Edited by admin on Wed Apr 02 19:47:42 GMT 2025
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER