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Details

Stereochemistry ACHIRAL
Molecular Formula Cu.O
Molecular Weight 79.545
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC OXIDE

SMILES

[O--].[Cu++]

InChI

InChIKey=KKCXRELNMOYFLS-UHFFFAOYSA-N
InChI=1S/Cu.O/q+2;-2

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlDOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.ncbi.nlm.nih.gov/pubmed/16971307https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www.ncbi.nlm.nih.gov/pubmed/6526221http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdf
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Cupric oxide is the oxide of the copper with the chemical formula of CuO. It is used in the ceramic industry for imparting blue, green or red tints in glasses, glazes and enamels. Cupric oxide is also used as a source for copper in food supplements. Copper is an essential nutrient and a normal constituent of the diet in man and animals. The average daily dietary requirement for copper in humans has been estimated at 0.03 mg/kg body weight. Although rare, copper deficiency has been induced by supplemental zinc therapy.

CNS Activity

CNS Active
3897
Curator's Comment: Known to be CNS active in zebrafish. Human data not available.

Originator

Smith, G.S.|Hoard, J.L.
35
Sources: Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).http://pubs.acs.org/doi/abs/10.1021/ja01512a012
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8146
 3.42 µM [Ki]
Ceruloplasmin
35
Target ID: P00450
Gene ID: 1356.0
Gene Symbol: CP
Target Organism: Homo sapiens (Human)
Binding Agent
1037
Target ID: Glutathione S-transferase, rat, liver
Binding Agent
1037
Modulator
817
Inhibitor
8146
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Preclinical
Unknown

Approved Use

Unknown
Preventing
Preclinical
Unknown

Approved Use

Unknown
Preventing
Approved
8307
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
Approved
8307
COPPER•MAX

Approved Use

Unknown
Primary
Not Provided
505
Unknown

Approved Use

Unknown
Preventing
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Diagnostic
Preclinical
Unknown

Approved Use

Unknown
Preventing
Approved
8307
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
Approved
8307
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
Efficacy of burning, tillage, and biocides in controlling bacteria released at field sites and effects on indigenous bacteria and fungi.
1992 Apr
The effect of various fluoride compounds on the development of experimental root surface caries in hamsters.
1995 Dec
The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa.
1995 Oct
Copper Fluoride Luminescence during UV Photofragmentation of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)copper(II) in the Gas Phase.
1996 Aug 14
Cardiopulmonary events during hemodialysis: effects of dialysis membranes and dialysate buffers.
2000 Jul
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions.
2001
Direct catalytic aldol-type reactions using RCH2CN.
2003 Aug 21
Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar.
2005 Mar 23
Cu(II) acetate- and Mn(III) acetate-mediated radical reactions of [60]fullerene with ketonic compounds.
2005 Mar 7
X-ray absorption spectroscopy study of a copper-containing material after thermal treatment.
2006 Apr 17
Acute copper toxicity following copper glycinate injection.
2006 Nov
A spectroscopic and thermoanalytical study of the mineral hoganite.
2007 May
Enhanced copper release from pipes by alternating stagnation and flow events.
2007 Nov 1
Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum.
2008 Jan
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes.
2009 Jan 16
Insight in the transport behavior of copper glycinate complexes through the porcine gastrointestinal membrane using an Ussing chamber assisted by mass spectrometry analysis.
2010 Apr
Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.
2010 Feb 3
A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy.
2010 Nov 3
Copper sulfide nanoparticles for photothermal ablation of tumor cells.
2010 Oct
Anti-ovulatory activity of H2 receptor blockers in albino rabbits--a preliminary study.
2011 Apr
Rapid free chlorine decay in the presence of Cu(OH)2: chemistry and practical implications.
2011 Oct 15
Expeditious synthesis of phenanthrenes via CuBr2-catalyzed coupling of terminal alkynes and N-tosylhydrazones derived from o-formyl biphenyls.
2011 Oct 7
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
2012 Feb
CuBr2--a new multiferroic material with high critical temperature.
2012 May 8
Evaluation of topically applied copper(II) oxide nanoparticle cytotoxicity in human skin organ culture.
2013 Feb
Probing the chemical nature of dihydrogen complexation to transition metals, a gas phase case study: H2-CuF.
2013 Jan 18
Design, synthesis, antioxidant, and anti-breast cancer activities of novel diethyl(alkyl/aryl/heteroarylamino)(4-(pyridin-2-yl)phenyl)methylphosphonates.
2013 May
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.
2013 Nov
Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.
2013 Nov 25
The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO₂ in human alveolar epithelial cells.
2013 Oct 24
SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.
2014
Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.
2014
Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.
2014
Synthesis and biomedical applications of copper sulfide nanoparticles: from sensors to theranostics.
2014 Feb 26
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.
2015 Jun
A Facile Strategy for Catalyst Separation and Recycling Suitable for ATRP of Hydrophilic Monomers Using a Macroligand.
2016 Jan
Dissecting copper homeostasis in diabetes mellitus.
2017 Apr
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride.
2017 Apr 1
Roles of Copper-Binding Proteins in Breast Cancer.
2017 Apr 20
Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities.
2017 Feb
Ultrasonic energy enhanced the efficiency of advance extraction methodology for enrichment of trace level of copper in serum samples of patients having neurological disorders.
2017 Jul
Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis.
2017 Jul
Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy.
2017 Jun
Amino acid-mediated 'turn-off/turn-on' nanozyme activity of gold nanoclusters for sensitive and selective detection of copper ions and histidine.
2017 Jun 15
Effects of Excess Copper Ions on Decidualization of Human Endometrial Stromal Cells.
2017 May
Patents

Patents

04904671
36
05034547
35
06203724
35
07465750
38
08399460
35
08722671
35
US2006191376
35
US20090239073 A1
35
US20090269269
35
US20160374209
35
US2046937 A
35
US2460067 A
35
US2533245 A
35
US3900504 A
35
US4020180 A
35
US6579328
35
US6670494
35
US7053251 B2
35
US7402296
35
US8921591
35
WO2003052039A1
35
WO2014001924A1
35
WO2017019802A1
35
WO9806419
35

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Veterinary drug
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration: Intravenous
In Vitro Use Guide
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class Chemical
Created
by admin
on Fri Dec 16 17:43:14 UTC 2022
Edited
by admin
on Fri Dec 16 17:43:14 UTC 2022
Record UNII
V1XJQ704R4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CUPRIC OXIDE
MI   VANDF   WHO-DD  
Common Name English
CUPRIC OXIDE [VANDF]
Common Name English
COPPER(II) OXIDE
HSDB  
Common Name English
C.I. 77403
Common Name English
COPPER(II) OXIDE [HSDB]
Common Name English
COPPER(2+) OXIDE
Common Name English
COPPER OXIDE (CUO)
Common Name English
C.I. PIGMENT BLACK 15
Common Name English
CUPRIC OXIDE [INCI]
Common Name English
CUPRUM OXYDATUM NIGRUM
HPUS   WHO-DD  
Common Name English
COPPER (AS CUPRIC OXIDE) [VANDF]
Common Name English
Cupric oxide [WHO-DD]
Common Name English
BLACK COPPER OXIDE
Common Name English
CUPRIC OXIDE [MI]
Common Name English
COOPER (AS CUPRIC OXIDE) [VANDF]
Common Name English
COPPER MONOXIDE
Common Name English
Cuprum oxydatum nigrum [WHO-DD]
Common Name English
NSC-83537
Code English
COPPER OXIDE
Common Name English
CUPRUM OXYDATUM NIGRUM [HPUS]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 42401
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
Code System Code Type Description
PUBCHEM
164827
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
RXCUI
21837
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY RxNorm
CHEBI
75955
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
DRUG CENTRAL
4291
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
MERCK INDEX
M3906
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY Merck Index
HSDB
266
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
DRUG BANK
DB11134
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
EVMPD
SUB13505MIG
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
CAS
1317-38-0
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
DAILYMED
V1XJQ704R4
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
MESH
C030973
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
FDA UNII
V1XJQ704R4
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
NSC
83537
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
WIKIPEDIA
COPPER(II) OXIDE
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
CONCEPT Industrial Aid
EPA CompTox
DTXSID5034488
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
ECHA (EC/EINECS)
215-269-1
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
NCI_THESAURUS
C75640
Created by admin on Fri Dec 16 17:43:14 UTC 2022 , Edited by admin on Fri Dec 16 17:43:14 UTC 2022
PRIMARY
Related Record Type Details
Structure of CUPRIC CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of CUPRIC OXIDE
ACTIVE MOIETY
Structure of CUPRIC CATION
ACTIVE MOIETY
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