LAGOCICLOVIR

NC1=NC2=C(N=CN2[C@H]3C[C@H](F)[C@@H](CO)O3)C(=O)N1

InChIKey=RTJUXLYUUDBAJN-KVQBGUIXSA-N

InChI=1S/C10H12FN5O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

LAGOCICLOVIR is a nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus and hepatitis B virus.

PubMed

Title	Date	PubMed
Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs.	1988 Dec	3219235
Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus.	1988 Mar	3258404
Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.	1996 Mar	8851615
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.	2000 Nov	11114413
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.	2005 Mar	15728915
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.	2006 Mar	16495257
Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B.	2009 Sep	19564357

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:37:54 GMT 2023` Edited by `admin` on `Sat Dec 16 17:37:54 GMT 2023`
Record UNII	UU109JJU0U
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

LAGOCICLOVIR

Official Name

English

lagociclovir [INN]

Common Name

English

Lagociclovir [WHO-DD]

Common Name

English

2-AMINO-9-(2,3-DIDEOXY-3-FLUORO-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ON

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C97452