U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Amlintide (amylin) is a 37 amino acid peptide hormone that is closely related to calcitonin gene-related peptide (CGRP). Amylin was originally discovered as the main component of islet amyloid deposition in patients with type 2 diabetes. Amylin and CGRP share a receptor and are reported to have several similar biological actions. Amylin's major role is as a glucoregulatory hormone, and it is an important regulator of energy metabolism in health and disease. Other amylin actions have also been reported, such as on the cardiovascular system or on bone. Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol. Amylin has been shown to have binding sites within the renal cortex in the area of the juxtaglomerular apparatus. Amylin has been shown to activate the rennin angiotensin aldosterone system. The amylin-based peptide, pramlintide, is used clinically to treat type 1 and type 2 diabetes. Pramlintide exhibits similar biologic activity to that of amylin. Clinical studies in obesity have shown that amylin agonists could also be useful for weight loss, especially in combination with other agents. Amylin is one of the few established gut/pancreatic hormones that has demonstrated durable, safe, tolerable, and clinically meaningful weight loss in humans.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

A rapid bolus of 50 ug of amlintide (synthetic human amylin) was injected in healthy subjects.
Route of Administration: Intravenous
MCF-7 cells endogenously express human Amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin results in the production of cAMP. The free, non-conjugated human Amylin results in an EC50 of 35.2±7.5 nM (r2=0.990), and the PEGylated human Amylin results in a EC50 of 30.8±6.7 nM (r=0.988)
Substance Class Protein
Created
by admin
on Fri Dec 15 16:25:21 UTC 2023
Edited
by admin
on Fri Dec 15 16:25:21 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
U3U3114NE1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMLINTIDE
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
ISLET AMYLOID POLYPEPTIDE (HUMAN)
Common Name English
amlintide [INN]
Common Name English
AMYLIN HUMAN AMYLIN
MI  
Common Name English
AC001
Code English
Amlintide [WHO-DD]
Common Name English
AMYLIN HUMAN AMYLIN [MI]
Common Name English
AMYLIN HUMAN
Common Name English
AC-001
Code English
AMLINTIDE [USAN]
Common Name English
Code System Code Type Description
CAS
122384-88-7
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
NCI_THESAURUS
C169781
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
FDA UNII
U3U3114NE1
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
PUBCHEM
16132430
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
ChEMBL
CHEMBL2109025
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
EVMPD
SUB33747
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
MERCK INDEX
m1873
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY Merck Index
INN
7447
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
USAN
GG-78
Created by admin on Fri Dec 15 16:25:21 UTC 2023 , Edited by admin on Fri Dec 15 16:25:21 UTC 2023
PRIMARY
From To
1_2 1_7
Related Record Type Details
MIMETIC->TARGET
MIMETIC->TARGET
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:CALCULATED CHEMICAL
Molecular Formula CHEMICAL