Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H21ClO4 |
Molecular Weight | 360.831 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2
InChI
InChIKey=YMTINGFKWWXKFG-UHFFFAOYSA-N
InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
Molecular Formula | C20H21ClO4 |
Molecular Weight | 360.831 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25903954
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25903954
Fenofibrate is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in people at risk of cardiovascular disease. It’s used as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is a fibric acid derivative, a prodrug comprising fenofibric acid linked to an isopropyl ester. Fenofibrate is rapidly hydrolyzed after oral ingestion to its pharmacologically active form, fenofibric acid. The effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα). It lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein CIII (an inhibitor of lipoprotein lipase activity), which increases lipolysis and elimination of triglyceride-rich particles from plasma. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. PPARα also increases apoproteins AI and AII, reduces VLDL- and LDL-containing apoprotein B, and increases HDL-containing apoprotein AI and AII.Fenofibrate also reduces serum uric acid levels in hyperuricemic and normal individuals by increasing the urinary excretion of uric acid. Fenofibrate also has an off-label use as uricosuric therapy in people who have gout.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25903954
Curator's Comment: fenofbrate cannot cross the blood-brain barrier and reach the central nervous system
Originator
Curator's Comment: Procetofen was synthesized in 1974 and was introduced in clinical practice in France the same year. Procetofen, which significantly decreased plasma lipid concentrations in hyperlipidemic patients, was later called fenofibrate to comply with World Health Organization nomenclature guidelines
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL239 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26693220 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | TRICOR Approved UseTreatment of Hypercholesterolemia. TRICOR is indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides
and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and non-pharmacological interventions alone has been inadequate (see National Cholesterol Education Program [NCEP] Treatment
Treatment of Hypertriglyceridemia: TRICOR is also indicated as adjunctive therapy to diet for treatment of adult patients with
hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Improving glycemic control in diabetic patients showing fasting chylomicronemia will usually reduce fasting triglycerides and eliminate chylomicronemia thereby obviating the need for pharmacologic intervention. Launch Date2004 |
|||
Palliative | TRICOR Approved UseTreatment of Hypercholesterolemia. TRICOR is indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides
and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and non-pharmacological interventions alone has been inadequate (see National Cholesterol Education Program [NCEP] Treatment
Treatment of Hypertriglyceridemia: TRICOR is also indicated as adjunctive therapy to diet for treatment of adult patients with
hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Improving glycemic control in diabetic patients showing fasting chylomicronemia will usually reduce fasting triglycerides and eliminate chylomicronemia thereby obviating the need for pharmacologic intervention. Launch Date2004 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.96 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27648957 |
67 mg single, oral dose: 67 mg route of administration: Oral experiment type: SINGLE co-administered: |
FENOFIBRIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
51.9 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27648957 |
67 mg single, oral dose: 67 mg route of administration: Oral experiment type: SINGLE co-administered: |
FENOFIBRIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
22.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27648957 |
67 mg single, oral dose: 67 mg route of administration: Oral experiment type: SINGLE co-administered: |
FENOFIBRIC ACID plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
16 h |
160 mg 1 times / day multiple, oral dose: 160 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
FENOFIBRIC ACID serum | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1% |
160 mg 1 times / day multiple, oral dose: 160 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
FENOFIBRIC ACID serum | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Other AEs: Asthenia, Pain... Other AEs: Asthenia (1.1%) Sources: Pain (1.1%) Headache (3.4%) Migraine (2.3%) Dyspepsia (2.3%) Gastrointestinal disorder (1.1%) Nausea (3.4%) Diarrhoea (1.1%) Myalgia (1.1%) Dizziness (1.1%) Abnormal thinking (1.1%) |
145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Other AEs: Abdominal pain, Back pain... Other AEs: Abdominal pain (4.6%) Sources: Back pain (3.4%) Headache (3.2%) Nausea (2.3%) Constipation (2.1%) Abnormal liver function tests (7.5%) ALT increased (3%) CPK increased (3%) AST increased (3.4%) Respiratory disorder (6.2%) Rhinitis (2.3%) Urticaria (1.1%) Rash (1.4%) |
200 mg 2 times / day multiple, oral Highest studied dose Dose: 200 mg, 2 times / day Route: oral Route: multiple Dose: 200 mg, 2 times / day Sources: |
unhealthy n = 46 Health Status: unhealthy Condition: hyperlipoproteinaemia Sex: M+F Population Size: 46 Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Abnormal thinking | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Asthenia | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Diarrhoea | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Dizziness | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Gastrointestinal disorder | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Myalgia | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Pain | 1.1% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Dyspepsia | 2.3% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Migraine | 2.3% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Headache | 3.4% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Nausea | 3.4% | 200 mg 1 times / day multiple, oral Dose: 200 mg, 1 times / day Route: oral Route: multiple Dose: 200 mg, 1 times / day Sources: |
unhealthy, 49.5 n = 87 Health Status: unhealthy Condition: dyslipidemia Age Group: 49.5 Sex: M+F Population Size: 87 Sources: |
Urticaria | 1.1% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Rash | 1.4% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Constipation | 2.1% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Nausea | 2.3% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Rhinitis | 2.3% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
ALT increased | 3% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
CPK increased | 3% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Headache | 3.2% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
AST increased | 3.4% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Back pain | 3.4% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Abdominal pain | 4.6% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Respiratory disorder | 6.2% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Abnormal liver function tests | 7.5% | 145 mg 1 times / day multiple, oral Recommended Dose: 145 mg, 1 times / day Route: oral Route: multiple Dose: 145 mg, 1 times / day Sources: |
unhealthy, adult n = 439 Health Status: unhealthy Condition: dyslipidemia Age Group: adult Population Size: 439 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Page: 3.0 |
moderate | |||
Page: 3.0 |
no | |||
Page: 3.0 |
no | |||
Page: 3.0 |
no | |||
Page: 3.0 |
no | |||
Page: 3.0 |
weak | |||
Page: 3.0 |
weak | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/26700956/ Page: 16.0 |
yes [IC50 170 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/15601807/ Page: 6.0 |
yes [IC50 2.39 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/14698041/ Page: 4.0 |
yes [IC50 5.83 uM] | |||
yes [Inhibition 50 uM] | ||||
yes [Ki 105.2 uM] | ||||
yes |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/14698041/ Page: 1.0 |
no | |||
yes | ||||
yes | ||||
yes | ||||
yes | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/15304429/ Page: 3.0 |
yes |
PubMed
Title | Date | PubMed |
---|---|---|
Severe toxic neuropathy due to fibrates. | 1999 Mar |
|
Advances in lipid-lowering therapy in atherosclerosis. | 2001 |
|
[Effects of hypolipidemic therapy on the endothelial dysfunction in patients with myocardial infarction at young age]. | 2001 |
|
Homocysteine elevation with fibrates: is it a class effect? | 2001 Apr |
|
The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C. | 2001 Dec 15 |
|
Benefits of micronised Fenofibrate in type 2 diabetes mellitus subjects with good glycemic control. | 2001 Feb 1 |
|
Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor alpha down-regulate platelet-activating-factor receptor expression in human macrophages. | 2001 Feb 15 |
|
Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. | 2001 Feb 23 |
|
Effects of atorvastatin versus fenofibrate on lipoprotein profiles, low-density lipoprotein subfraction distribution, and hemorheologic parameters in type 2 diabetes mellitus with mixed hyperlipoproteinemia. | 2001 Jan 1 |
|
Fibrate-induced increase in blood urea and creatinine. | 2001 Jul |
|
Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate. | 2001 Jul 13 |
|
Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2): promoter analysis and role of the peroxisome proliferator-activated receptor PPARalpha. | 2001 Jun |
|
Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. | 2001 May 29 |
|
Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial--FAT). | 2001 Nov |
|
High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists. | 2001 Sep 21 |
|
[Effect of phenofibrate treatment on endothelial dysfunction in patients with history of myocardial infarction in young age]. | 2002 |
|
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. | 2002 Apr 5 |
|
Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. | 2002 Feb |
|
A pharmacoepidemiological assessment of the effect of statins and fibrates on fibrinogen concentration. | 2002 Jan |
|
PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells. | 2002 Jan 25 |
|
Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists. | 2002 Jan 25 |
|
A laser flash photolysis study of fenofibric acid in aqueous buffered media: unexpected triplet state inversion in a derivative of 4-alkoxybenzophenone. | 2002 Mar |
|
Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. | 2002 Mar 15 |
|
Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. | 2002 May |
Sample Use Guides
Primary Hypercholesterolemia or Mixed Hyperlipidemia: the initial dose of TRICOR (FENOFIBRATE TABLETS) is 145 mg per day
Hypertriglyceridemia: the initial dose is 48 to 145 mg per day
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27629528
Fenofibrate may protect against endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiachypertrophy and heart failure.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:00:21 GMT 2023
by
admin
on
Fri Dec 15 15:00:21 GMT 2023
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Record UNII |
U202363UOS
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000175375
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WHO-VATC |
QC10BA03
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WHO-ATC |
C10BA04
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LIVERTOX |
NBK548607
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NCI_THESAURUS |
C98150
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WHO-VATC |
QC10AB05
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WHO-ATC |
C10BA03
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WHO-ATC |
C10AB05
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WHO-VATC |
QC10BA04
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N0000170118
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N0000175596
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N0000170118
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FENOFIBRATE
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m5279
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3339
Created by
admin on Fri Dec 15 15:00:21 GMT 2023 , Edited by admin on Fri Dec 15 15:00:21 GMT 2023
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100000092530
Created by
admin on Fri Dec 15 15:00:21 GMT 2023 , Edited by admin on Fri Dec 15 15:00:21 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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BINDER->LIGAND |
BINDING
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TRANSPORTER -> INHIBITOR |
Related Record | Type | Details | ||
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METABOLITE ACTIVE -> PRODRUG |
Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Biological Half-life | PHARMACOKINETIC |
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