HUMAN TRANSFORMING GROWTH FACTOR .BETA.-1

Approval Year

Substance Class	Protein
Protein Type	GROWTH FACTOR
Protein Sub Type	TGF .BETA. SUPERFAMILY
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	T7D25J14LT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRANSFORMING GROWTH FACTOR BETA-1

Preferred Name

English

HUMAN TRANSFORMING GROWTH FACTOR .BETA.-1

Common Name

English

RH-POLYPEPTIDE-22 [INCI]

Common Name

English

TRANSFORMING GROWTH FACTOR .BETA.-1

Common Name

English

TGF-.BETA. 1

Brand Name

English

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Code System

Code

Type

Description

FDA UNII

T7D25J14LT

PRIMARY

UNIPROT

P01137

PRIMARY

DAILYMED

T7D25J14LT

PRIMARY

NCI_THESAURUS

C1293

PRIMARY

RXCUI

1426465

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_7	1_16
1_15	1_78
1_44	1_109
1_48	1_111
1_77	2_77

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Related Record

Type

Details


					4AR6718OL0

METELIMUMAB

LIGAND->TARGET

Amount:


					ZVV0Y45KAQ

TONOGENCONCEL

VECTOR->EXPRESSED PROTEIN

Amount:


					ZT3VR2T6GY

COTSIRANIB

INHIBITOR OF EXPRESSION->TARGET

Amount:


					375142VBIA

FRESOLIMUMAB

INHIBITOR -> TARGET

Amount:


					FT06VU379M

TGF-BETA RECEPTOR TYPE-1

TARGET -> AGONIST

Comments:

TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer.

Amount:

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Related Record

Type

Details


					T7D25J14LT

HUMAN TRANSFORMING GROWTH FACTOR .BETA.-1

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C1152H1740N304O318S20
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 25600 Da (average)

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