U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C22H25NO6
Molecular Weight 399.4378
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COLCHICINE

SMILES

CC(=N[C@@]1([H])CCc2cc(c(c(c2-c3ccc(c(=O)cc31)OC)OC)OC)OC)O

InChI

InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H25NO6
Molecular Weight 399.4378
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Colchicine is an alkaloid obtained from the plant colchicum autumnale (also known as "meadow saffron"). Colchicine is an alternative medication for those unable to tolerate NSAIDs in gout. Mechanism of action of colchicine is inhibition of microtubule polymerization by binding to tubulin. Availability of tubulin is essential to mitosis, so colchicine effectively unctions as a "mitotic poison" or spindle poison.

CNS Activity

Curator's Comment:: Known to be CNS non-penetrant in rats. Human data not available.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
COLCRYS

Approved Use

Colchicine capsules are indicated for prophylaxis of gout flares in adults. Colchicine disrupts the polymerization of β-tubulin into microtubules, thereby preventing the activation, degranulation, and migration of neutrophils to sites of inflammation.

Launch Date

1248912000000
Primary
COLCRYS

Approved Use

Colchicine is indicated for Familial Mediterranean fever (FMF) in adults and children 4 years or older

Launch Date

1248912000000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.68 ng/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
2.16 ng/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
2023.29 pg/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: oral
experiment type: single
co-administered:
COLCHICINE plasma
Homo sapiens
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
18.47 ng × h/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
19.9 ng × h/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
8717.33 pg*h/mL
0.6 mg single, oral
dose: 0.6 mg
route of administration: oral
experiment type: single
co-administered:
COLCHICINE plasma
Homo sapiens
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
30.54 h
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
31.04 h
0.6 mg single, oral
dose: 0.6 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
COLCHICINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
61%
COLCHICINE serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unknown, 42 years
Health Status: unknown
Age Group: 42 years
Sex: M
Sources:
Other AEs: Myelosuppression...
Other AEs:
Myelosuppression (grade 4, 1 patient)
Sources:
3 mg 1 times / day multiple, oral
MTD
Dose: 3 mg, 1 times / day
Route: oral
Route: multiple
Dose: 3 mg, 1 times / day
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Other AEs: Nausea, Vomiting...
Other AEs:
Nausea (27%)
Vomiting (13%)
Diarrhea (20%)
Injection site reactions (20%)
Myalgia (27%)
Arthralgia (7%)
Allergic reaction (7%)
Sources:
12 mg single, oral
Overdose
Dose: 12 mg
Route: oral
Route: single
Dose: 12 mg
Sources:
unknown, 56 years
Health Status: unknown
Age Group: 56 years
Sex: M
Sources:
Other AEs: Rhabdomyolysis...
Other AEs:
Rhabdomyolysis (grade 5, 1 patient)
Sources:
1 mg 1 times / day multiple, oral
Recommended
Dose: 1 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, 79 years
Health Status: unhealthy
Age Group: 79 years
Sex: M
Sources:
Disc. AE: Acute pancreatitis, Epigastric pain...
AEs leading to
discontinuation/dose reduction:
Acute pancreatitis (1 patient)
Epigastric pain (severe, 1 patient)
Nausea (1 patient)
Vomiting (1 patient)
Sources:
0.6 mg 2 times / day multiple, oral
Dose: 0.6 mg, 2 times / day
Route: oral
Route: multiple
Dose: 0.6 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Other AEs: Acute respiratory distress syndrome, Fall...
Other AEs:
Acute respiratory distress syndrome (serious, 3 patients)
Fall (serious, 2 patients)
Sources:
AEs

AEs

AESignificanceDosePopulation
Myelosuppression grade 4, 1 patient
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unknown, 42 years
Health Status: unknown
Age Group: 42 years
Sex: M
Sources:
Vomiting 13%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Diarrhea 20%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Injection site reactions 20%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Myalgia 27%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Nausea 27%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Allergic reaction 7%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Arthralgia 7%
1 mg 1 times / week multiple, intravenous
Dose: 1 mg, 1 times / week
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / week
Sources:
unhealthy, 44 years (range: 39.5–48.5 years)
Health Status: unhealthy
Age Group: 44 years (range: 39.5–48.5 years)
Sex: M+F
Sources:
Rhabdomyolysis grade 5, 1 patient
12 mg single, oral
Overdose
Dose: 12 mg
Route: oral
Route: single
Dose: 12 mg
Sources:
unknown, 56 years
Health Status: unknown
Age Group: 56 years
Sex: M
Sources:
Acute pancreatitis 1 patient
Disc. AE
1 mg 1 times / day multiple, oral
Recommended
Dose: 1 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, 79 years
Health Status: unhealthy
Age Group: 79 years
Sex: M
Sources:
Nausea 1 patient
Disc. AE
1 mg 1 times / day multiple, oral
Recommended
Dose: 1 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, 79 years
Health Status: unhealthy
Age Group: 79 years
Sex: M
Sources:
Vomiting 1 patient
Disc. AE
1 mg 1 times / day multiple, oral
Recommended
Dose: 1 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, 79 years
Health Status: unhealthy
Age Group: 79 years
Sex: M
Sources:
Epigastric pain severe, 1 patient
Disc. AE
1 mg 1 times / day multiple, oral
Recommended
Dose: 1 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, 79 years
Health Status: unhealthy
Age Group: 79 years
Sex: M
Sources:
Fall serious, 2 patients
0.6 mg 2 times / day multiple, oral
Dose: 0.6 mg, 2 times / day
Route: oral
Route: multiple
Dose: 0.6 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Acute respiratory distress syndrome serious, 3 patients
0.6 mg 2 times / day multiple, oral
Dose: 0.6 mg, 2 times / day
Route: oral
Route: multiple
Dose: 0.6 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
yes
likely (co-administration study)
Comment: Although there are no published case reports for colchicine toxicity when co-administered with the 4 inhibitors that the sponsor employed, i.e., voriconazole, fluconazole, cimetidine and propafenone, several published case reports indicate that colchicine toxicity is observed when it is co-administered with drugs that are potent inhibitors of both P-gp and CYP3A4 (e.g., clarithromycin, ketoconazole) as well as potent P-gp inhibitors (e.g., cyclosporine).
Page: 2
yes
yes (co-administration study)
Comment: Co-administration with posaconazole (considered a strong CYP3A4 inhibitor) increased AUC of colchcine by approximately 3-fold; Although there are no published case reports for colchicine toxicity when co-administered with the 4 inhibitors that the sponsor employed, i.e., voriconazole, fluconazole, cimetidine and propafenone, several published case reports indicate that colchicine toxicity is observed when it is co-administered with drugs that are potent inhibitors of both P-gp and CYP3A4 (e.g., clarithromycin, ketoconazole) and strong to moderate inhibitors of CYP3A4 (e.g., grapefruit juice, erythromycin).
Page: 2
PubMed

PubMed

TitleDatePubMed
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
1991 Jan-Feb
[Toxic myopathy with kidney failure as a colchicine side effect ifn familial Mediterranean fever].
1992 Aug 14
Colchicine myoneuropathy and renal dysfunction.
1992 Dec
Rapid-onset colchicine myoneuropathy.
1992 Dec
Acute neuromyopathy after colchicine treatment.
1992 Nov
Danggui shaoyao san improve colchichine-induced learning acquisition impairment in rats.
2001 Dec
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats.
2001 Dec
[Treatment of AL-amyloidosis and some other types of amyloidosis].
2001 Jan
Developing a model of colchicine neuropathy.
2002
Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications.
2002 Dec
Colchicine-induced myopathy with normal creatine phosphokinase level in a renal transplant patient.
2002 Dec
[Summary of the Dutch College of General Practitioners' "Gout" Standard].
2002 Feb 16
Colchicine myoneuropathy in a renal transplant patient.
2002 Jul
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.
2002 Jul
[Myopathy caused by colchicine with myotonia].
2002 Jul 16-31
Colchicine neuromyopathy: a report of six cases.
2002 Jul-Aug
Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells.
2002 Mar
Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.
2002 Nov 15
Colchicine-induced acute myopathy in a patient with concomitant use of simvastatin.
2002 Sep-Oct
Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles.
2003 Aug
Colchicine myopathy in a patient with familial Mediterranean fever and normal renal function.
2003 Aug 15
Colchicine-induced rhabdomyolysis in a patient with chronic heart failure.
2003 Dec
Colchicine induces apoptosis in organotypic hippocampal slice cultures.
2003 Feb 28
The role of the cytoskeleton in mechanotransduction in human osteoblast-like cells.
2003 May
Differential effects of stretch and compression on membrane currents and [Na+]c in ventricular myocytes.
2003 May-Jul
Case report. Hepatic portal venous gas: transient radiographic finding associated with colchicine toxicity.
2003 Nov
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.
2003 Oct
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2003. A 37-year-old man with a history of alcohol and drug abuse and sudden onset of leg weakness.
2003 Oct 23
Colchicine-induced myopathy with myotonia in a patient with chronic renal failure.
2003 Sep
[Neurotoxic effects of medications: an update].
2004
Lithium prevents colchicine-induced apoptosis in rat cerebellar granule neurons.
2004 Apr
Colchicine myotoxicity: case reports and literature review.
2004 Dec
Cytoskeletal myotoxicity from simvastatin and colchicine.
2004 Dec
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
2004 Dec
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance.
2004 Dec 20
Effects of colchicine on liver functions of cirrhotic rats: beneficial effects result from stellate cell inactivation and inhibition of TGF beta1 expression.
2004 Jan 15
[Abdominal pain and recurrent cholestatic jaundice].
2004 Jun 9
Acute poisoning with autumn crocus (Colchicum autumnale L.).
2004 Mar 31
Establishment of a P-glycoprotein substrate screening model and its preliminary application.
2004 May 1
[Experimental study on Sorbaria sorbifolia extract against chronic liver damage in rats].
2004 Oct
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.
2004 Oct 1
RhoA/ROCK and Cdc42 regulate cell-cell contact and N-cadherin protein level during neurodetermination of P19 embryonal stem cells.
2004 Sep 5
Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium.
2005
Establishment and characterization of new cellular lymphoma model expressing transgenic human MDR1.
2005 Apr
[Nephrogenic diabetes insipidus induced by colchicine--a case report].
2005 Sep
An unusual cause of renal amyloidosis secondary to gout: the first description of familial occurrence.
2006
Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
2006 Aug
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
2006 Jul 26
[Effect of the ethyl acetate extract of zhi ju zi on serum makers and the expression of TGF-beta1 in rats with hepatic fibrosis].
2006 Jun
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption.
2006 Mar
Patents

Sample Use Guides

In Vivo Use Guide
For prophylaxis of gout flares, the recommended dosage of Colchicine capsules is 0.6 mg once or twice daily. The maximum dose is 1.2 mg per day. Colchicine capsules are administered orally, without regard to meals.
Route of Administration: Oral
In Vitro Use Guide
Inhibition of the polymerization of brain tubulin was evaluated. Solution of compound in DMSO in serial dilutions was prepared. Reaction mixture contained 0.25 mg of tubulin, 1.0 M monosodium glutamate and approptiate drug concentrations. The reaction mixtures were incubated at 37 °C for 15 min to allow slow binding drugs like colchicine to bind to the tubulin. The reaction mixtures were then chilled on ice, and the polymerization reaction was followed turbidimetrically for 20 min. Polymer formation was confirmed by evaluation of depolymerization at 0°C. Extent of inhibition of polymerization at 20 min in drug-treated samples was always calculated by comparing them to a pair of drug-free samples in each experimental set.
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:16:51 UTC 2021
Edited
by admin
on Fri Jun 25 21:16:51 UTC 2021
Record UNII
SML2Y3J35T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COLCHICINE
EP   HSDB   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
Common Name English
NSC-757
Code English
COLCHICINUM
HPUS   WHO-IP LATIN  
Common Name English
ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-
Common Name English
COLCHICINE COMPONENT OF PROBEN-C
Common Name English
COLCHICINE [WHO-IP]
Common Name English
(S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE
Systematic Name English
COLBENEMID COMPONENT COLCHICINE
Common Name English
COLCHICINE COMPONENT OF COLBENEMID
Common Name English
COLCHICINE COMPONENT OF COL-PROBENECID
Common Name English
COLCHICINE [USP]
Common Name English
COLCHICINE [USP-RS]
Common Name English
COLCHCINE [VANDF]
Common Name English
COLCHICINE [WHO-DD]
Common Name English
COLCHICINE [EP]
Common Name English
GLOPERBA
Brand Name English
(-)-COLCHICINE
Common Name English
MITIGARE COMPONENT COLCHICINE
Brand Name English
PROBEN-C COMPONENT COLCHICINE
Common Name English
COLCHICINUM [WHO-IP LATIN]
Common Name English
COLCRYS
Brand Name English
COLCHINEOS
Common Name English
COLCHICINE [ORANGE BOOK]
Common Name English
COLCHICINE COMPONENT OF MITIGARE
Brand Name English
COLCHICINE [MI]
Common Name English
COLCHICINUM [HPUS]
Common Name English
COLCHICINE [EP MONOGRAPH]
Common Name English
COLCHICINE [JAN]
Common Name English
COLCHICINE [MART.]
Common Name English
COL-PROBENECID COMPONENT COLCHICINE
Common Name English
COLCHISOL
Common Name English
COLCHICINE [HSDB]
Common Name English
Classification Tree Code System Code
WHO-VATC QM04AC01
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
FDA ORPHAN DRUG 11085
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
FDA ORPHAN DRUG 245707
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
FDA ORPHAN DRUG 245807
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
NCI_THESAURUS C67421
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
WHO-ATC M04AC01
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
LIVERTOX 234
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
Code System Code Type Description
ECHA (EC/EINECS)
200-598-5
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
HSDB
3044
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
COLCHICINE
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY Description: Pale yellow to pale greenish yellow crystals, amorphous scales or a powder; odourless or almost odourless.Solubility: Soluble in water; freely soluble in ethanol (~750 g/l) TS; slightly soluble in ether R.Category: Antigout drug.Storage: Colchicine should be kept in a tightly closed container, protected from light.Additional information: Colchicine is an alkaloid obtained from Colchicum autumnale L. (Fam. Liliaceae). It darkens on exposureto light. CAUTION: Colchicine is extremely poisonous and must be handled with care.
LACTMED
Colchicine
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
MERCK INDEX
M3725
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY Merck Index
FDA UNII
SML2Y3J35T
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
MESH
D003078
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
ChEMBL
CHEMBL107
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
PUBCHEM
6167
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
NDF-RT
N0000000239
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY P-Glycoprotein Interactions [MoA]
NDF-RT
N0000182141
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY Cytochrome P450 3A4 Inhibitors [MoA]
CAS
64-86-8
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
NCI_THESAURUS
C385
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
EPA CompTox
64-86-8
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
DRUG CENTRAL
726
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
IUPHAR
2367
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
RXCUI
2683
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
COLCHICINE
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
EVMPD
SUB01420MIG
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
DRUG BANK
DB01394
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY
USP_CATALOG
1146006
Created by admin on Fri Jun 25 21:16:51 UTC 2021 , Edited by admin on Fri Jun 25 21:16:51 UTC 2021
PRIMARY USP-RS
Related Record Type Details
BINDER->LIGAND
BINDING
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
TRANSPORTER -> SUBSTRATE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC