U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:09:12 GMT 2023
Edited
by admin
on Sat Dec 16 14:09:12 GMT 2023
Protein Sub Type
Record UNII
74UG0EWZ60
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TUBULIN BETA CHAIN
Common Name English
TUBULIN BETA-5 CHAIN
Common Name English
TUBB5
Common Name English
Code System Code Type Description
FDA UNII
74UG0EWZ60
Created by admin on Sat Dec 16 14:09:13 GMT 2023 , Edited by admin on Sat Dec 16 14:09:13 GMT 2023
PRIMARY
UNIPROT
P07437
Created by admin on Sat Dec 16 14:09:13 GMT 2023 , Edited by admin on Sat Dec 16 14:09:13 GMT 2023
PRIMARY
Glycosylation Link Type Site
N 1_184
N 1_337
N 1_370
Related Record Type Details
INHIBITOR -> TARGET
Binds to the colchicine site on β-tubulin that leads to a block in the cell cycle at the G2M phase, resulting in cellular apoptosis
LIGAND->TARGET
INHIBITOR OF AGGREGATION->TARGET
DESTABILIZED TUBULIN POLYMERS
LIGAND->TARGET
binds to the colchicine-binding site on tubulin and interferes in microtubule processing.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR OF AGGREGATION->TARGET
DESTABILIZES TUBULIN POLYMERS
INHIBITOR -> TARGET
LIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR OF AGGREGATION->TARGET
DESTABILIZES TUBULIN POLYMERS
INHIBITOR -> TARGET
INHIBITOR OF AGGREGATION->TARGET
LIGAND->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL