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Details

Stereochemistry ACHIRAL
Molecular Formula C23H15ClF2N4O3
Molecular Weight 468.84
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BMS-794833

SMILES

NC1=C(Cl)C(OC2=C(F)C=C(NC(=O)C3=CNC=C(C3=O)C4=CC=C(F)C=C4)C=C2)=CC=N1

InChI

InChIKey=PDYXPCKITKHFOZ-UHFFFAOYSA-N
InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32)

HIDE SMILES / InChI
Molecular Formula C23H15ClF2N4O3
Molecular Weight 468.84
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ejcancersupplements.com/article/S1359-6349(10)71801-2/abstract | http://www.ejcancersupplements.com/article/S1359-6349(10)71811-5/abstract | http://adisinsight.springer.com/drugs/800022289 | http://adisinsight.springer.com/drugs/800046444

BMS-794833 (N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-5-(4- fluorophenyl)-4-oxo-l,4-dihydropyridine-3-carboxamide) is an inhibitor of Met, VEGFR2, Ron, Axl and Flt-3 kinases. BMS-794833 demonstrated dose-dependent tumor growth inhibition following oral administration in xenograft models. In cell culture, BMS-794833 inhibited the proliferation of human tumor cell lines containing constitutively activated Met receptor. BMS-794833 is an active moety of pro-drug BMS-817378. Bristol-Myers Squibb and Simcere Pharmaceutical Group are developing BMS-817378 for treatment of cancer.

CNS Activity

CNS Active
3828
Curator's Comment: Brain penetration of BMS-794833 is unknown, however BMS-794833 demonstrates antitumor activity against U87 glioblastoma xenografts

Originator

Bristol-Myers Squibb
145
Curator's Comment: # Bristol-Myers Squibb

Approval Year

Unknown
134361
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8228
 1.7 nM [IC50]
Inhibitor
8228
 15.0 nM [IC50]
Macrophage-stimulating protein receptor
4
Target ID: CHEMBL2689
Sources: DOI: 10.1016/S1359-6349(10)71801-2
Inhibitor
8228
 3.0 nM [IC50]
Tyrosine-protein kinase receptor UFO
13
Target ID: CHEMBL4895
Sources: DOI: 10.1016/S1359-6349(10)71801-2
Inhibitor
8228
 3.0 nM [IC50]
Tyrosine-protein kinase receptor FLT3
43
Target ID: CHEMBL1974
Sources: DOI: 10.1016/S1359-6349(10)71801-2
Inhibitor
8228
 3.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase I
424
Unknown

Approved Use

Unknown
Patents

Patents

WO2009094417A1
1

Sample Use Guides

In Vivo Use Guide
antitumor activity of BMS-794833 dosed orally once daily for 14 days 6.25 mpk (mg/kg), 12.5 mpk, and 25 mpk was tested against U87 glioblastoma xenografts.
Route of Administration: Oral
In Vitro Use Guide
Sources: DOI: 10.1016/S1359-6349(10)71801-2 https://google.com/patents/WO2009094417A1
Curator's Comment: BMS-794833 inhibited the proliferation of human tumor cell lines containing constitutively activated Met receptor (GTL-16 gastric carcinoma)
Unknown
Substance Class Chemical
Created
by admin
on Thu Jul 06 23:47:36 UTC 2023
Edited
by admin
on Thu Jul 06 23:47:36 UTC 2023
Record UNII
SAY8KVM4HU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BMS-794833
Code English
3-PYRIDINECARBOXAMIDE, N-(4-((2-AMINO-3-CHLORO-4-PYRIDINYL)OXY)-3-FLUOROPHENYL)-5-(4-FLUOROPHENYL)-1,4-DIHYDRO-4-OXO-
Systematic Name English
Code System Code Type Description
CAS
1174046-72-0
Created by admin on Thu Jul 06 23:47:36 UTC 2023 , Edited by admin on Thu Jul 06 23:47:36 UTC 2023
PRIMARY
FDA UNII
SAY8KVM4HU
Created by admin on Thu Jul 06 23:47:36 UTC 2023 , Edited by admin on Thu Jul 06 23:47:36 UTC 2023
PRIMARY
PUBCHEM
44155856
Created by admin on Thu Jul 06 23:47:36 UTC 2023 , Edited by admin on Thu Jul 06 23:47:36 UTC 2023
PRIMARY
EPA CompTox
DTXSID30657662
Created by admin on Thu Jul 06 23:47:36 UTC 2023 , Edited by admin on Thu Jul 06 23:47:36 UTC 2023
PRIMARY
Related Record Type Details
RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3
TARGET -> INHIBITOR
IC50
TYROSINE-PROTEIN KINASE MER
TARGET -> INHIBITOR
IC50
TYROSINE-PROTEIN KINASE RECEPTOR UFO
TARGET -> INHIBITOR
IC50
TYROSINE-PROTEIN KINASE RECEPTOR TYRO3
TARGET -> INHIBITOR
IC50
NIH
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