THONZYLAMINE

US Approved OTC

First approved in 1948

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22N4O
Molecular Weight	286.3721
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(CN(CCN(C)C)C2=NC=CC=N2)C=C1

InChI

InChIKey=GULNIHOSWFYMRN-UHFFFAOYSA-N

InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C16H22N4O
Molecular Weight	286.3721
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18869262 | https://www.ncbi.nlm.nih.gov/pubmed/14891823 | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e133352-255f-41cc-aacc-0508d634368d

Thonzylamine (also known as neohetramine) is an antihistamine and anticholinergic drug, which is used in combination with others compounds for the temporarily relieves symptoms due to the common cold: hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion; runny nose and so on. In addition, thonzylamine was investigated for the treatment of tuberculosis, when this drug caused a slight reduction in the extent of tuberculosis in experimentally infected guinea pigs and caused a slight but significant increase in the length of survival.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Nasal congestion 27 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e133352-255f-41cc-aacc-0508d634368d	Palliative	Approved 8583	NASOPEN PE Approved Use Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes Launch Date 2012
Itching 52 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e133352-255f-41cc-aacc-0508d634368d	Palliative	Approved 8583	NASOPEN PE Approved Use Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes Launch Date 2012
Runny nose 2 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e133352-255f-41cc-aacc-0508d634368d	Palliative	Approved 8583	NASOPEN PE Approved Use Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes Launch Date 2012
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14891823	Primary	Preclinical	Unknown Approved Use Unknown
Sneezing 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e133352-255f-41cc-aacc-0508d634368d	Palliative	Approved 8583	NASOPEN PE Approved Use Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes Launch Date 2012

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY579207	https://www.001chemical.com/chem/91-85-0
Achemo Scientific Limited	AC-102462	http://www.achemo.com/search/?Keyword=91-85-0
AK Scientific, Inc. (AKSCI)	5504AC	http://www.aksci.com/item_detail.php?cat=5504AC
Ambinter	Amb22002585	http://www.ambinter.com/reference/22002585
Angel Pharmatech	AG112530	http://www.angelpharmatech.com/91-85-0.html
Aurora Fine Chemicals LLC	A13.112.054	http://online.aurorafinechemicals.com/info?ID=A13.112.054
BioChemPartner	BCP25799	http://www.biochempartner.com/91-85-0-BCP25799
BLD Pharm	BD154003	http://www.bldpharm.com/products/91-85-0.html
Chem Scene	CS-0013078	http://www.chemscene.com/91-85-0.html
Chemspace	CSSS00020618067	https://chem-space.com/CSSS00020618067
eNovation Chemicals	D281146	https://www.enovationchem.com/ProductDetails.asp?ProductID=D281146
eNovation Chemicals	Y1078288	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1078288
Matrix Scientific	99597	https://www.matrixscientific.com/099597.html
Molcore	MC579207	https://www.molcore.com/product/91-85-0
Smolecule	S593277	https://www.smolecule.com/products/s593277
THE BioTek	bt-458996	https://www.thebiotek.com/product/others/bt-458996

PubMed

Title	Date	PubMed
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.	2010	22291486

Patents

Sample Use Guides

In Vivo Use Guide

Adults and children 12 years of age and over: 15 mL (1 TBSP) every 4 hours, not to exceed 90 mL (6 TBSP) in a 24 hour period. Children 6 to under 12 years of age: 7.5 mL (1/2 TBSP) every 4 hours, not to exceed 45 mL (3 TBSP) in a 24 hour period.

Route of Administration: Nasal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:16:37 GMT 2025` Edited by `admin` on `Wed Apr 02 09:16:37 GMT 2025`
Record UNII	R79646H5Z8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TONAMIL

Preferred Name

English

THONZYLAMINE

Official Name

English

thonzylamine [INN]

Common Name

English

2-((2-(DIMETHYLAMINO)ETHYL)(P-METHOXYBENZYL)AMINO)PYRIMIDINE

Common Name

English

Thonzylamine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578