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Details

Stereochemistry ACHIRAL
Molecular Formula C16H22N4O
Molecular Weight 286.3721
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THONZYLAMINE

SMILES

COC1=CC=C(CN(CCN(C)C)C2=NC=CC=N2)C=C1

InChI

InChIKey=GULNIHOSWFYMRN-UHFFFAOYSA-N
InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C16H22N4O
Molecular Weight 286.3721
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thonzylamine (also known as neohetramine) is an antihistamine and anticholinergic drug, which is used in combination with others compounds for the temporarily relieves symptoms due to the common cold: hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion; runny nose and so on. In addition, thonzylamine was investigated for the treatment of tuberculosis, when this drug caused a slight reduction in the extent of tuberculosis in experimentally infected guinea pigs and caused a slight but significant increase in the length of survival.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
NASOPEN PE
Palliative
NASOPEN PE
Palliative
NASOPEN PE
Primary
Unknown
Palliative
NASOPEN PE

PubMed

Sample Use Guides

In Vivo Use Guide
Adults and children 12 years of age and over: 15 mL (1 TBSP) every 4 hours, not to exceed 90 mL (6 TBSP) in a 24 hour period. Children 6 to under 12 years of age: 7.5 mL (1/2 TBSP) every 4 hours, not to exceed 45 mL (3 TBSP) in a 24 hour period.
Route of Administration: Nasal
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
R79646H5Z8
Record Status Validated (UNII)
Record Version