U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H22N4O.ClH
Molecular Weight 322.833
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THONZYLAMINE HYDROCHLORIDE

SMILES

Cl.COC1=CC=C(CN(CCN(C)C)C2=NC=CC=N2)C=C1

InChI

InChIKey=HRYJPHOTGFERGT-UHFFFAOYSA-N
InChI=1S/C16H22N4O.ClH/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14;/h4-10H,11-13H2,1-3H3;1H

HIDE SMILES / InChI
Molecular Formula C16H22N4O
Molecular Weight 286.3721
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thonzylamine (also known as neohetramine) is an antihistamine and anticholinergic drug, which is used in combination with others compounds for the temporarily relieves symptoms due to the common cold: hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion; runny nose and so on. In addition, thonzylamine was investigated for the treatment of tuberculosis, when this drug caused a slight reduction in the extent of tuberculosis in experimentally infected guinea pigs and caused a slight but significant increase in the length of survival.

Approval Year

1948
95
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

1.34913602E12
Palliative
Approved
8429
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

1.34913602E12
Palliative
Approved
8429
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

1.34913602E12
Primary
Preclinical
Unknown

Approved Use

Unknown
Palliative
Approved
8429
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

1.34913602E12
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY579207
https://www.001chemical.com/chem/91-85-0
AK Scientific, Inc. (AKSCI)
5504AC
http://www.aksci.com/item_detail.php?cat=5504AC
Achemo Scientific Limited
AC-102462
http://www.achemo.com/search/?Keyword=91-85-0
Ambinter
Amb22002585
http://www.ambinter.com/reference/22002585
Angel Pharmatech
AG112530
http://www.angelpharmatech.com/91-85-0.html
Aurora Fine Chemicals LLC
A13.112.054
http://online.aurorafinechemicals.com/info?ID=A13.112.054
BLD Pharm
BD154003
http://www.bldpharm.com/products/91-85-0.html
BioChemPartner
BCP25799
http://www.biochempartner.com/91-85-0-BCP25799
Chem Scene
CS-0013078
http://www.chemscene.com/91-85-0.html
Chemspace
CSSS00020618067
https://chem-space.com/CSSS00020618067
Matrix Scientific
99597
https://www.matrixscientific.com/099597.html
Molcore
MC579207
https://www.molcore.com/product/91-85-0
Smolecule
S593277
https://www.smolecule.com/products/s593277
THE BioTek
bt-458996
https://www.thebiotek.com/product/others/bt-458996
eNovation Chemicals
D281146
https://www.enovationchem.com/ProductDetails.asp?ProductID=D281146
eNovation Chemicals
Y1078288
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1078288
PubMed

PubMed

TitleDatePubMed
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.
2010
Patents

Patents

CA2802362A1
2
US2730483
2

Sample Use Guides

In Vivo Use Guide
Adults and children 12 years of age and over: 15 mL (1 TBSP) every 4 hours, not to exceed 90 mL (6 TBSP) in a 24 hour period. Children 6 to under 12 years of age: 7.5 mL (1/2 TBSP) every 4 hours, not to exceed 45 mL (3 TBSP) in a 24 hour period.
Route of Administration: Nasal
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:06:05 UTC 2023
Edited
by admin
on Fri Dec 15 15:06:05 UTC 2023
Record UNII
6K9YKD48Y4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THONZYLAMINE HYDROCHLORIDE
JAN   MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
THONZYLAMINE HYDROCHLORIDE [JAN]
Common Name English
NSC-758388
Code English
2-((2-(DIMETHYLAMINO)ETHYL)(P-METHOXYBENZYL)AMINO)PYRIMIDINE HYDROCHLORIDE
Common Name English
THONZYLAMINE HYDROCHLORIDE [USAN]
Common Name English
THONZYLAMINE HCL
Common Name English
SUPER ANAHIST
Brand Name English
THONZYLAMINE HYDROCHLORIDE [MART.]
Common Name English
THONZYLAMINE HYDROCHLORIDE [MI]
Common Name English
Thonzylamine hydrochloride [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 341.12
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
Code System Code Type Description
NSC
758388
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
DAILYMED
6K9YKD48Y4
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-561-3
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
NCI_THESAURUS
C84205
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
MERCK INDEX
m10797
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1623738
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
CAS
63-56-9
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
EVMPD
SUB04825MIG
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
EPA CompTox
DTXSID8026147
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
MESH
C100145
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
SMS_ID
100000084912
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
DRUG BANK
DBSALT001562
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
RXCUI
1360720
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY RxNorm
FDA UNII
6K9YKD48Y4
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
PUBCHEM
6136
Created by admin on Fri Dec 15 15:06:05 UTC 2023 , Edited by admin on Fri Dec 15 15:06:05 UTC 2023
PRIMARY
Related Record Type Details
Structure of THONZYLAMINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of THONZYLAMINE
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