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Details

Stereochemistry EPIMERIC
Molecular Formula C17H24NO3
Molecular Weight 290.3774
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 4
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of METHYLHOMATROPINE

SMILES

C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3

InChI

InChIKey=WKWOJBUWWZTUQV-SPUOUPEWSA-N
InChI=1S/C17H24NO3/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12/h3-7,13-16,19H,8-11H2,1-2H3/q+1/t13-,14+,15+,16?

HIDE SMILES / InChI

Molecular Formula C17H23NO3
Molecular Weight 289.3694
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 3 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
350.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PARATROPINA

Approved Use

For spasmodic pains & disorders of the GIT eg irritable colon, mucous colitis, colicky pains, peptic ulcer, pylorospasm, cardiospasm, flatulence, nausea, vomiting & hyperacidity
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Structure-activity requirements for hypotension and alpha-adrenergic receptor blockade by analogues of atropine.
1983 May 20
Patents

Patents

Sample Use Guides

Oral administration: 40 drops of paratropin should be dissolved in a glass of water and administered orally.
Route of Administration: Oral
In Vitro Use Guide
The brains from SD rats were removed following decapitation, dissected free of membranes, and the cerebella discarded. Tissues were then homogenized with a Brinkmann Polytron in 20 vol of ice cold Tris-HCl buffer (50 mM, pH 7.7). The homogenates were centrifuged at 40000 × g for 10 min at 4°C and the pellets resuspended in the buffer at a concentration of 50 mg wet weight/ml. Radioligand displacement binding studies were performed using 0.06 nM of [3H]QNB and 0.2-0.4 mg protein. The Kd value for [3H]QNB was previously determined in our laboratory to be 0.1 nM. Analysis of the results was performed as described above. Methylhomatropine displaces radioligand with Ki of 350 nM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 21:09:10 UTC 2023
Edited
by admin
on Fri Dec 15 21:09:10 UTC 2023
Record UNII
P97OGJ7L1L
Record Status Validated (UNII)
Record Version
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Name Type Language
METHYLHOMATROPINE
WHO-DD  
Common Name English
METHYLHOMATROPINE ION
Common Name English
(±)-METHYLHOMATROPINE
Common Name English
METHYLHOMATROPINE CATION
Common Name English
1.ALPHA.H,5.ALPHA.H-TROPANIUM, 3.ALPHA.-HYDROXY-8-METHYL-, MANDELATE (ESTER)
Common Name English
Methylhomatropine [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC A03CB04
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
WHO-VATC QA03CB04
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
Code System Code Type Description
RXCUI
1546413
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY RxNorm
DAILYMED
P97OGJ7L1L
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
EPA CompTox
DTXSID10858832
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
FDA UNII
P97OGJ7L1L
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
CAS
31610-86-3
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
DRUG CENTRAL
1380
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
PUBCHEM
5282592
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
WIKIPEDIA
METHYLHOMATROPINE
Created by admin on Fri Dec 15 21:09:10 UTC 2023 , Edited by admin on Fri Dec 15 21:09:10 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY