| Stereochemistry | EPIMERIC |
| Molecular Formula | C17H24NO3.NO3 |
| Molecular Weight | 352.3823 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+]([O-])=O.C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3
InChI
InChIKey=DRTHYWDOFIVHKK-RIMUKSHESA-N
InChI=1S/C17H24NO3.NO3/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;2-1(3)4/h3-7,13-16,19H,8-11H2,1-2H3;/q+1;-1/t13-,14+,15+,16?;
| Molecular Formula | NO3 |
| Molecular Weight | 62.0049 |
| Charge | -1 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H24NO3 |
| Molecular Weight | 290.3774 |
| Charge | 1 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.
CNS Activity
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
Oral administration: 40 drops of paratropin should be dissolved in a glass of water and administered orally.
Route of Administration:
Oral
The brains from SD rats were removed following decapitation, dissected free of membranes, and the cerebella discarded. Tissues were then homogenized with a Brinkmann Polytron in 20 vol of ice cold Tris-HCl buffer (50 mM, pH 7.7). The homogenates were centrifuged at 40000 × g for 10 min at 4°C and the pellets resuspended in the buffer at a concentration of 50 mg wet weight/ml. Radioligand displacement binding studies were performed using 0.06 nM of [3H]QNB and 0.2-0.4 mg protein. The Kd value for [3H]QNB was previously determined in our laboratory to be 0.1 nM. Analysis of the results was performed as described above. Methylhomatropine displaces radioligand with Ki of 350 nM.
