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Details

Stereochemistry EPIMERIC
Molecular Formula C17H24NO3.Br
Molecular Weight 370.2815
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HOMATROPINE METHYLBROMIDE

SMILES

C[N+]1(C)[C@@]2([H])CC[C@]1([H])C[C@@]([H])(C2)OC(=O)C([H])(c3ccccc3)O.[Br-]

InChI

InChIKey=FUFVKLQESJNNAN-RIMUKSHESA-M
InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?;

HIDE SMILES / InChI

Molecular Formula C17H23NO3
Molecular Weight 289.3701
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 2 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula BrH
Molecular Weight 80.9115
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
350.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PARATROPINA

Approved Use

For spasmodic pains & disorders of the GIT eg irritable colon, mucous colitis, colicky pains, peptic ulcer, pylorospasm, cardiospasm, flatulence, nausea, vomiting & hyperacidity
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

Oral administration: 40 drops of paratropin should be dissolved in a glass of water and administered orally.
Route of Administration: Oral
In Vitro Use Guide
The brains from SD rats were removed following decapitation, dissected free of membranes, and the cerebella discarded. Tissues were then homogenized with a Brinkmann Polytron in 20 vol of ice cold Tris-HCl buffer (50 mM, pH 7.7). The homogenates were centrifuged at 40000 × g for 10 min at 4°C and the pellets resuspended in the buffer at a concentration of 50 mg wet weight/ml. Radioligand displacement binding studies were performed using 0.06 nM of [3H]QNB and 0.2-0.4 mg protein. The Kd value for [3H]QNB was previously determined in our laboratory to be 0.1 nM. Analysis of the results was performed as described above. Methylhomatropine displaces radioligand with Ki of 350 nM.
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:17:34 UTC 2021
Edited
by admin
on Fri Jun 25 21:17:34 UTC 2021
Record UNII
68JRS2HC1C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HOMATROPINE METHYLBROMIDE
EP   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
HOMAPIN
Brand Name English
HOMATROPINE METHYLBROMIDE COMPONENT OF TUSSIGON
Common Name English
EQUIPIN
Brand Name English
HOMATROPINE METHYLBROMIDE [WHO-IP]
Common Name English
8-AZONIABICYCLO(3.2.1)OCTANE, 3-((HYDROXYPHENYLACETYL)OXY)-8,8-DIMETHYL-, BROMIDE, ENDO-
Common Name English
HOMATROPINI METHYLBROMIDUM [WHO-IP LATIN]
Common Name English
HOMATROPINE METHYLBROMIDE [WHO-DD]
Common Name English
HYDROPANE COMPONENT HOMATROPINE METHYLBROMIDE
Common Name English
3.ALPHA.-HYDROXY-8-METHYL-1.ALPHA.H,5.ALPHA.H-TROPANIUM BROMIDE MANDELATE
Common Name English
HOMATROPINE METHYLBROMIDE [VANDF]
Common Name English
HOMATROPINE METHYLBROMIDE [USP-RS]
Common Name English
HOMATROPINE METHYLBROMIDE [INN]
Common Name English
HYCODAN COMPONENT HOMATROPINE METHYLBROMIDE
Common Name English
HOMATROPINE METHYLBROMIDE [MART.]
Common Name English
HOMATROPINE METHYLBROMIDE COMPONENT OF HYDROPANE
Common Name English
HOMATROPINE METHYLBROMIDE COMPONENT OF HYCODAN
Common Name English
HOMATROPINE METHYLBROMIDE [USP]
Common Name English
HOMATROPINE METHYLBROMIDE [ORANGE BOOK]
Common Name English
NSC-34399
Code English
HOMATROPINE METHYLBROMIDE [MI]
Common Name English
HOMATROPINE METHYLBROMIDE [EP MONOGRAPH]
Common Name English
TUSSIGON COMPONENT HOMATROPINE METHYLBROMIDE
Common Name English
NSC-757048
Code English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C61784
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
MESH
C056244
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
FDA UNII
68JRS2HC1C
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
DRUG BANK
DB00725
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
USP_CATALOG
1311000
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY USP-RS
EVMPD
SUB08048MIG
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201235
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
EPA CompTox
80-49-9
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
HOMATROPINE METHYLBROMIDE
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY Description: A white, crystalline powder; odourless. Solubility: Very soluble in water; freely soluble in ethanol (~750 g/l) TS; practically insoluble in ether R and acetone R. Category: Mydriatic. Storage: Homatropine methylbromide should be kept in a tightly closed container, protected from light. Additional information: Homatropine methylbromide darkens on exposure to light. Requirement: Homatropine methylbromide contains not less than 98.5% and not more than the equivalent of 101.0% of C17H24BrNO3, calculated with reference to the dried substance.
CAS
80-49-9
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
RXCUI
27085
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY RxNorm
INN
131
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
ECHA (EC/EINECS)
201-284-0
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY
MERCK INDEX
M6038
Created by admin on Fri Jun 25 21:17:34 UTC 2021 , Edited by admin on Fri Jun 25 21:17:34 UTC 2021
PRIMARY Merck Index
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IMPURITY -> PARENT
IMPURITY -> PARENT
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ACTIVE MOIETY