ELEDOISIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13890700 | https://www.ncbi.nlm.nih.gov/pubmed/12037144

Eledoisin is an endecapeptide tachykinin receptor ligand. Originally it was isolated from salivary glands of Mediterranean octopod, Eledone moschata. Eledoisin is a powerful vasodilator and hypotensive agent in most animal species.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.	1996-08-23	8702757
Molecular characterisation, expression and localisation of human neurokinin-3 receptor.	1992-03-24	1312036

Patents

Patents

Substance Class	Protein Created by `admin` on `Mon Mar 31 18:14:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:58 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	OKY3285J18
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ELEDOISIN

Official Name

English

ELD 950

Preferred Name

English

ELEDOISIN [MART.]

Common Name

English

PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2

Common Name

English

5-OXO-L-PROLYL-L-PROLYL-L-SERYL-L-LYSYL-L-ASPARTYL-L-ALANYL-L-PHENYLALANYL-L-ISOLEUCYLGLYCYL-L-LEUCYL-L-METHIONINAMIDE

Common Name

English

5-OXOPRO-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2

Common Name

English

ELD-950

Code

English

Eledoisin [WHO-DD]

Common Name

English

eledoisin [INN]

Common Name

English

ELEDOISIN [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C894

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

Code System Code Type Description

CAS

69-25-0

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

PRIMARY

MERCK INDEX

m4858

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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Merck Index

NCI_THESAURUS

C80866

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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EPA CompTox

DTXSID1046926

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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FDA UNII

OKY3285J18

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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WIKIPEDIA

ELEDOISIN

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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SMS_ID

100000080541

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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INN

3278

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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PUBCHEM

10328936

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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ChEMBL

CHEMBL373569

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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EVMPD

SUB06481MIG

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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DRUG CENTRAL

2955

Created by admin on Mon Mar 31 18:14:58 GMT 2025 , Edited by admin on Mon Mar 31 18:14:58 GMT 2025

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Related Record Type Details


					T9L8F7448X

ELEDOISIN TRIFLUOROACETATE

SALT/SOLVATE -> PARENT


					T9L8F7448X

ELEDOISIN TRIFLUOROACETATE

INGREDIENT -> STARTING MATERIAL


					2PHC2A2Z52

ELEDOISIN SESQUIHYDRATE

INGREDIENT -> STARTING MATERIAL

Related Record Type Details


					OKY3285J18

ELEDOISIN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUION	[1_11]		METHIONINE		METHIONINAMIDE	QSM06A70MD
AMINO ACID SUBSTITUION	[1_1]		PROLINE		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL