LOSULAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H22F4N4O3S
Molecular Weight	558.547
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=C5C=CC(=CC5=NC=C4)C(F)(F)F)C=C3

InChI

InChIKey=SYJKIRZBDWNJSB-UHFFFAOYSA-N

InChI=1S/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)

HIDE SMILES / InChI

Molecular Formula	C27H22F4N4O3S
Molecular Weight	558.547
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6822289 | https://www.ncbi.nlm.nih.gov/pubmed/3941407 | https://www.ncbi.nlm.nih.gov/pubmed/4017421

Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.

Originator

Approval Year

PubMed

Title	Date	PubMed
Losulazine, a new antihypertensive.	1985 Aug	4017421
7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics.	1986 Jan	3941407
Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride.	1987 Jan	3099429
Study on the activities of testes and accessory sex glands after losulazine treatment in rats.	1994 Sep	8091426

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:07:07 GMT 2023` Edited by `admin` on `Fri Dec 15 19:07:07 GMT 2023`
Record UNII	O2978JQ9B7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOSULAZINE

Official Name

English

1-((P-FLUOROPHENYL)SULFONYL)-4-(P-((7-(TRIFLUOROMETHYL)-4-QUINOLYL)AMINO)BENZOYL)PIPERAZINE

Common Name

English

losulazine [INN]

Common Name

English

Code System Code Type Description

CAS

72141-57-2