Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H22F4N4O3S.ClH.H2O |
| Molecular Weight | 613.023 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Cl.FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=CC=NC5=CC(=CC=C45)C(F)(F)F)C=C3
InChI
InChIKey=FLWHGDVIICGHDP-UHFFFAOYSA-N
InChI=1S/C27H22F4N4O3S.ClH.H2O/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;;/h1-12,17H,13-16H2,(H,32,33);1H;1H2
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C27H22F4N4O3S |
| Molecular Weight | 558.547 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Study on the activities of testes and accessory sex glands after losulazine treatment in rats. | 1994-09 |
|
| Comparison of the effects of losulazine and reserpine on central aminergic neurons. | 1993-11 |
|
| Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride. | 1987-01 |
|
| 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. | 1986-01 |
|
| Losulazine, a new antihypertensive. | 1985-08 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:36:37 GMT 2025
by
admin
on
Mon Mar 31 17:36:37 GMT 2025
|
| Record UNII |
267UX099PD
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6917756
Created by
admin on Mon Mar 31 17:36:37 GMT 2025 , Edited by admin on Mon Mar 31 17:36:37 GMT 2025
|
PRIMARY | |||
|
267UX099PD
Created by
admin on Mon Mar 31 17:36:37 GMT 2025 , Edited by admin on Mon Mar 31 17:36:37 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ANHYDROUS->SOLVATE | |||
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |