LOSULAZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H22F4N4O3S.ClH
Molecular Weight	595.008
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=C5C=CC(=CC5=NC=C4)C(F)(F)F)C=C3

InChI

InChIKey=MGOGSSZOPFFXLA-UHFFFAOYSA-N

InChI=1S/C27H22F4N4O3S.ClH/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;/h1-12,17H,13-16H2,(H,32,33);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C27H22F4N4O3S
Molecular Weight	558.547
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6822289 | https://www.ncbi.nlm.nih.gov/pubmed/3941407 | https://www.ncbi.nlm.nih.gov/pubmed/4017421

Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.

Originator

Approval Year

PubMed

Title	Date	PubMed
Losulazine, a new antihypertensive.	1985 Aug	4017421
7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics.	1986 Jan	3941407
Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride.	1987 Jan	3099429
Comparison of the effects of losulazine and reserpine on central aminergic neurons.	1993 Nov	8236258
Study on the activities of testes and accessory sex glands after losulazine treatment in rats.	1994 Sep	8091426

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:43:21 GMT 2023` Edited by `admin` on `Sat Dec 16 01:43:21 GMT 2023`
Record UNII	8PK0TPX321
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOSULAZINE HYDROCHLORIDE

Official Name

English

LOSULAZINE HYDROCHLORIDE [USAN]

Common Name

English

METHANONE, (4-((4-FLUOROPHENYL)SULFONYL)-1-PIPERAZINYL)(4-((7-(TRIFLUOROMETHYL)-4-QUINOLINYL)AMINO)PHENYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

U-54,669F

Code

English

U-54669F

Code

English

Code System Code Type Description

NCI_THESAURUS

C175117