LOSULAZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H22F4N4O3S.ClH
Molecular Weight	595.008
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=C5C=CC(=CC5=NC=C4)C(F)(F)F)C=C3

InChI

InChIKey=MGOGSSZOPFFXLA-UHFFFAOYSA-N

InChI=1S/C27H22F4N4O3S.ClH/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;/h1-12,17H,13-16H2,(H,32,33);1H

HIDE SMILES / InChI

Molecular Formula	C27H22F4N4O3S
Molecular Weight	558.547
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6822289 | https://www.ncbi.nlm.nih.gov/pubmed/3941407 | https://www.ncbi.nlm.nih.gov/pubmed/4017421

Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.

Originator

Approval Year

PubMed

Title	Date	PubMed
Study on the activities of testes and accessory sex glands after losulazine treatment in rats.	1994-09	8091426
Comparison of the effects of losulazine and reserpine on central aminergic neurons.	1993-11	8236258
Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride.	1987-01	3099429
7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics.	1986-01	3941407
Losulazine, a new antihypertensive.	1985-08	4017421

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:59:05 GMT 2025` Edited by `admin` on `Mon Mar 31 20:59:05 GMT 2025`
Record UNII	8PK0TPX321
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOSULAZINE HYDROCHLORIDE

Official Name

English

U-54,669F

Preferred Name

English

LOSULAZINE HYDROCHLORIDE [USAN]

Common Name

English

METHANONE, (4-((4-FLUOROPHENYL)SULFONYL)-1-PIPERAZINYL)(4-((7-(TRIFLUOROMETHYL)-4-QUINOLINYL)AMINO)PHENYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

U-54669F

Code

English

Code System Code Type Description

NCI_THESAURUS

C175117