Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C72H101N17O26 |
Molecular Weight | 1620.6706 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 13 / 13 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]3[C@@H](C)OC(=O)[C@H](CC(=O)C4=CC=CC=C4N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC3=O)[C@H](C)CC(O)=O
InChI
InChIKey=DOAKLVKFURWEDJ-QCMAZARJSA-N
InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45-,46+,47+,48+,49+,50-,60+,61+/m1/s1
Molecular Formula | C72H101N17O26 |
Molecular Weight | 1620.6706 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 13 / 13 |
E/Z Centers | 4 |
Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including: https://www.drugbank.ca/drugs/DB00080
Curator's Comment: description was created based on several sources, including: https://www.drugbank.ca/drugs/DB00080
Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function. It inserts into the cell membrane in a phosphatidylglycerol-dependent fashion, where it then aggregates. The aggregation of daptomycin alters the curvature of the membrane, which creates holes that leak ions. This causes rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death. Daptomycin is bactericidal against Gram-positive bacteria only. It has proven in vitro activity against enterococci (including glycopeptide-resistant enterococci (GRE)), staphylococci (including methicillin-resistant Staphylococcus aureus), streptococci, corynebacteria and stationary-phase Borrelia burgdorferi persisters.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL352 |
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Target ID: CHEMBL612624 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20176900 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | CUBICIN Approved UseCUBICIN® is indicated for the treatment of the infections listed below. CUBICIN is a lipopeptide antibacterial indicated for the treatment of: Complicated skin and skin structure infections (cSSSI) (1.1) Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis (1.2) CUBICIN is not indicated for the treatment of pneumonia. (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of CUBICIN and other antibacterial drugs, CUBICIN should be used to treat infections that are proven or strongly suspected to be caused by bacteria. 1.1 Complicated Skin and Skin Structure Infections Complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only). 1.2 Staphylococcus aureus Bloodstream Infections (Bacteremia), Including Those with Right-Sided Infective Endocarditis, Caused by Methicillin-Susceptible and Methicillin-Resistant Isolates Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis, caused by methicillin-susceptible and methicillin-resistant isolates. 1.3 Limitations of Use CUBICIN is not indicated for the treatment of pneumonia. CUBICIN is not indicated for the treatment of left-sided infective endocarditis due to S. aureus. The clinical trial of CUBICIN in patients with S. aureus bloodstream infections included limited data from patients with left-sided infective endocarditis; outcomes in these patients were poor [see Clinical Trials (14.2) Launch Date1.06332481E12 |
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Curative | CUBICIN Approved UseCUBICIN® is indicated for the treatment of the infections listed below. CUBICIN is a lipopeptide antibacterial indicated for the treatment of: Complicated skin and skin structure infections (cSSSI) (1.1) Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis (1.2) CUBICIN is not indicated for the treatment of pneumonia. (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of CUBICIN and other antibacterial drugs, CUBICIN should be used to treat infections that are proven or strongly suspected to be caused by bacteria. 1.1 Complicated Skin and Skin Structure Infections Complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only). 1.2 Staphylococcus aureus Bloodstream Infections (Bacteremia), Including Those with Right-Sided Infective Endocarditis, Caused by Methicillin-Susceptible and Methicillin-Resistant Isolates Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis, caused by methicillin-susceptible and methicillin-resistant isolates. 1.3 Limitations of Use CUBICIN is not indicated for the treatment of pneumonia. CUBICIN is not indicated for the treatment of left-sided infective endocarditis due to S. aureus. The clinical trial of CUBICIN in patients with S. aureus bloodstream infections included limited data from patients with left-sided infective endocarditis; outcomes in these patients were poor [see Clinical Trials (14.2) Launch Date1.06332481E12 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
141.1 μg/mL |
10 mg/kg 1 times / day steady-state, intravenous dose: 10 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
183.7 μg/mL |
12 mg/kg 1 times / day steady-state, intravenous dose: 12 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
57.8 μg/mL |
4 mg/kg 1 times / day steady-state, intravenous dose: 4 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
93.9 μg/mL |
6 mg/kg 1 times / day steady-state, intravenous dose: 6 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
123.3 μg/mL |
8 mg/kg 1 times / day steady-state, intravenous dose: 8 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
59.1 ug/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00428844 |
6 mg/kg 1 times / day steady, intravenous dose: 6 mg/kg route of administration: intravenous experiment type: steady co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: unhealthy age: Adults sex: F+M food status: |
|
92.3 ug/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00428844 |
8 mg/kg 1 times / day steady, intravenous dose: 8 mg/kg route of administration: intravenous experiment type: steady co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: unhealthy age: Adults sex: F+M food status: |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1039 μg × h/mL |
10 mg/kg 1 times / day steady-state, intravenous dose: 10 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
1277 μg × h/mL |
12 mg/kg 1 times / day steady-state, intravenous dose: 12 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
494 μg × h/mL |
4 mg/kg 1 times / day steady-state, intravenous dose: 4 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
632 μg × h/mL |
6 mg/kg 1 times / day steady-state, intravenous dose: 6 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
858 μg × h/mL |
8 mg/kg 1 times / day steady-state, intravenous dose: 8 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
499 ug*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00428844 |
6 mg/kg 1 times / day steady, intravenous dose: 6 mg/kg route of administration: intravenous experiment type: steady co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: unhealthy age: Adults sex: F+M food status: |
|
821 ug*h/mL Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00428844 |
8 mg/kg 1 times / day steady, intravenous dose: 8 mg/kg route of administration: intravenous experiment type: steady co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: unhealthy age: Adults sex: F+M food status: |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.9 h |
10 mg/kg 1 times / day steady-state, intravenous dose: 10 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7.7 h |
12 mg/kg 1 times / day steady-state, intravenous dose: 12 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.1 h |
4 mg/kg 1 times / day steady-state, intravenous dose: 4 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7.9 h |
6 mg/kg 1 times / day steady-state, intravenous dose: 6 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.3 h |
8 mg/kg 1 times / day steady-state, intravenous dose: 8 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
8.5% |
4 mg/kg 1 times / day steady-state, intravenous dose: 4 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
DAPTOMYCIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
10 mg/kg single, intravenous Highest studied dose Dose: 10 mg/kg Route: intravenous Route: single Dose: 10 mg/kg Sources: |
unhealthy, 2 - 6 years n = 6 Health Status: unhealthy Condition: bacterial infection Age Group: 2 - 6 years Sex: M+F Population Size: 6 Sources: |
|
6 mg/kg 1 times / day steady, intravenous Recommended Dose: 6 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 6 mg/kg, 1 times / day Sources: |
unhealthy, 21 - 87 years n = 120 Health Status: unhealthy Condition: bacterial infection Age Group: 21 - 87 years Sex: M+F Population Size: 120 Sources: |
Disc. AE: Creatine kinase increased, Renal impairment... AEs leading to discontinuation/dose reduction: Creatine kinase increased (3 patients) Sources: Renal impairment (1 patient) Death (18 patients) |
6 mg/kg single, intravenous Recommended Dose: 6 mg/kg Route: intravenous Route: single Dose: 6 mg/kg Sources: |
unhealthy, 3–24 Months Health Status: unhealthy Condition: proven/suspected bacterial infection Age Group: 3–24 Months Sex: M+F Sources: |
|
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Disc. AE: Cardiac failure, Hypocalcemia... AEs leading to discontinuation/dose reduction: Cardiac failure (4 patients) Sources: Hypocalcemia (grade 4, 1 patient) Acute renal failure (1 patient) Acute liver injury (1 patient) Gastrointestinal bleeding (1 patient) Nausea and vomiting (2 patients) |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Sources: |
unhealthy, 62 - 80 years n = 81 Health Status: unhealthy Condition: bacterial infection Age Group: 62 - 80 years Sex: M+F Population Size: 81 Sources: |
Disc. AE: Acute renal failure, Respiratory failure... AEs leading to discontinuation/dose reduction: Acute renal failure (1 patient) Sources: Respiratory failure (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Renal impairment | 1 patient Disc. AE |
6 mg/kg 1 times / day steady, intravenous Recommended Dose: 6 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 6 mg/kg, 1 times / day Sources: |
unhealthy, 21 - 87 years n = 120 Health Status: unhealthy Condition: bacterial infection Age Group: 21 - 87 years Sex: M+F Population Size: 120 Sources: |
Death | 18 patients Disc. AE |
6 mg/kg 1 times / day steady, intravenous Recommended Dose: 6 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 6 mg/kg, 1 times / day Sources: |
unhealthy, 21 - 87 years n = 120 Health Status: unhealthy Condition: bacterial infection Age Group: 21 - 87 years Sex: M+F Population Size: 120 Sources: |
Creatine kinase increased | 3 patients Disc. AE |
6 mg/kg 1 times / day steady, intravenous Recommended Dose: 6 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 6 mg/kg, 1 times / day Sources: |
unhealthy, 21 - 87 years n = 120 Health Status: unhealthy Condition: bacterial infection Age Group: 21 - 87 years Sex: M+F Population Size: 120 Sources: |
Acute liver injury | 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Acute renal failure | 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Gastrointestinal bleeding | 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Nausea and vomiting | 2 patients Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Cardiac failure | 4 patients Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Hypocalcemia | grade 4, 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Co-administed with:: fosfomycin(2 g) Sources: |
unhealthy, 60.8 - 80.8 years n = 74 Health Status: unhealthy Condition: bacterial infection Age Group: 60.8 - 80.8 years Sex: M+F Population Size: 74 Sources: |
Acute renal failure | 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Sources: |
unhealthy, 62 - 80 years n = 81 Health Status: unhealthy Condition: bacterial infection Age Group: 62 - 80 years Sex: M+F Population Size: 81 Sources: |
Respiratory failure | 1 patient Disc. AE |
10 mg/kg 1 times / day steady, intravenous Recommended Dose: 10 mg/kg, 1 times / day Route: intravenous Route: steady Dose: 10 mg/kg, 1 times / day Sources: |
unhealthy, 62 - 80 years n = 81 Health Status: unhealthy Condition: bacterial infection Age Group: 62 - 80 years Sex: M+F Population Size: 81 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely | ||||
unlikely |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
yes |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-572_Cubicin_Pharmr.pdf#page=9 Page: 9.0 |
PubMed
Title | Date | PubMed |
---|---|---|
Influence of daptomycin on staphylococcal abscesses and experimental tobramycin nephrotoxicity. | 1989 Aug |
|
Muscle pain associated with daptomycin. | 2004 Nov |
|
Methicillin-resistant Staphylococcus aureus prosthetic aortic valve endocarditis with paravalvular abscess treated with daptomycin. | 2005 Jan-Feb |
|
Successful treatment of Corynebacterium striatum endocarditis with daptomycin plus rifampin. | 2005 Oct |
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Comparative activity of the new lipoglycopeptide telavancin in the presence and absence of serum against 50 glycopeptide non-susceptible staphylococci and three vancomycin-resistant Staphylococcus aureus. | 2006 Aug |
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Rhabdomyolysis and acute renal failure in a patient treated with daptomycin. | 2006 Mar |
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Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram of body weight once daily in healthy volunteers. | 2006 Oct |
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Eosinophilic pneumonia induced by daptomycin. | 2007 Apr |
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Community-phenotype-methicillin-resistant Staphylococcus aureus infections: a retrospective chart review of outcomes after treatment with daptomycin. | 2007 Nov |
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Daptomycin in the treatment of patients with infective endocarditis: experience from a registry. | 2007 Oct |
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Daptomycin in the treatment of bacteremia. | 2007 Oct |
|
Successful treatment of vancomycin-resistant Enterococcus faecium pyelonephritis with daptomycin during pregnancy. | 2008 May |
|
Non-susceptibility trends among staphylococci from bacteraemias in the UK and Ireland, 2001-06. | 2008 Nov |
|
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains. | 2009 Apr |
|
Treatment of meningitis caused by vancomycin-resistant Enterococcus faecium: high-dose and combination daptomycin therapy. | 2010 Dec |
|
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | 2015 May 18 |
Sample Use Guides
4 mg/kg once every 24 hours (every 48 hours if creatinine clearance <30 mL/min)
6 mg/kg once every 24 hours (every 48 hours if creatinine clearance <30 mL/min)
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16870765
In vitro activities of daptomycin was studied against more than 100 strains each of Clostridium difficile, C. perfringens, Finegoldia magna, and Propionibacterium acnes. For 392 of 421 strains (93%), daptomycin was inhibitory at <1 g/ml,
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:00:48 UTC 2023
by
admin
on
Sat Dec 16 17:00:48 UTC 2023
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Record UNII |
NWQ5N31VKK
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000175509
Created by
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NDF-RT |
N0000175508
Created by
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WHO-VATC |
QJ01XX09
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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NCI_THESAURUS |
C2363
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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EMA ASSESSMENT REPORTS |
CUBICIN (AUTHORIZED: ENDOCARDITIS, BACTERIAL)
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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WHO-ATC |
J01XX09
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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EMA ASSESSMENT REPORTS |
CUBICIN (AUTHORIZED: BACTEREMIA)
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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NDF-RT |
N0000175508
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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LIVERTOX |
NBK548746
Created by
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NWQ5N31VKK
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NWQ5N31VKK
Created by
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21585658
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783
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DTXSID1041009
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22299
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Y-79
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Daptomycin
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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D017576
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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C47470
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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DB00080
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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600103
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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SUB06910MIG
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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DAPTOMYCIN
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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CHEMBL387675
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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103060-53-3
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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m4093
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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6127
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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100000085430
Created by
admin on Sat Dec 16 17:00:49 UTC 2023 , Edited by admin on Sat Dec 16 17:00:49 UTC 2023
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Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
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METABOLIC ENZYME -> NON-INHIBITOR |
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BINDER->LIGAND |
BINDING
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Volume of Distribution | PHARMACOKINETIC |
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Biological Half-life | PHARMACOKINETIC |
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