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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3.ClH.2H2O
Molecular Weight 371.856
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CODEINE HYDROCHLORIDE

SMILES

O.O.Cl.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC

InChI

InChIKey=AWFZELCPUGEQGQ-NLMNJOOOSA-N
InChI=1S/C18H21NO3.ClH.2H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;;;/h3-6,11-13,17,20H,7-9H2,1-2H3;1H;2*1H2/t11-,12+,13-,17-,18-;;;/m0.../s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H21NO3
Molecular Weight 299.3642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
6.1 µM [EC50]
Target ID: P41145
Gene ID: 4986.0
Gene Symbol: OPRK1
Target Organism: Homo sapiens (Human)
Target ID: P41143
Gene ID: 4985.0
Gene Symbol: OPRD1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CAPITAL AND CODEINE

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Pharmacokinetic and toxicokinetic parameters of some drugs of abuse].
2001
Determination of opiates in serum, saliva and hair addicted persons.
2001
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis.
2001
The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs.
2001 Apr
Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
2001 Apr
The diagnosis and treatment of cough.
2001 Apr 5
The safety of dextromethorphan in pregnancy : results of a controlled study.
2001 Feb
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
2001 Jan
Successful use of propranolol in migraine associated with electroconvulsive therapy.
2001 Jan
Packaging of codeine phosphate suppositories.
2001 Jan
Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine.
2001 Jul 27
Use of beta-cyclodextrin in the capillary zone electrophoretic separation of the components of clandestine heroin preparations.
2001 Jul 27
[Chronic pain in geriatrics].
2001 Jun
Oral ibuprofen versus paracetamol plus codeine for analgesia after ambulatory surgery.
2001 Jun
Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.
2001 Mar
Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.
2001 Mar
Generalized eczema due to codeine.
2001 Mar
Evaluation of urinary dihydrocodeine excretion in human by gas chromatography-mass spectrometry.
2001 Mar 5
Effect of an enteric-release formulation of naloxone on intestinal transit in volunteers taking codeine.
2001 May
Selective antibodies to methadone enantiomers: synthesis of (R)- and (R,S)-methadone conjugates and determination by an immunoenzymatic method in human serum.
2001 May 5
From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial.
2001 May-Jun
Scalp nerve blocks decrease the severity of pain after craniotomy.
2001 Nov
Nutritional effects of surgical and medical treatment for short bowel syndrome.
2001 Nov-Dec
Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays.
2001 Oct
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
2001 Oct
Endogenous morphine and codeine. Possible role as endogenous anticonvulsants.
2001 Oct 12
Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999.
2001 Sep
Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial.
2001 Sep
[Strong opioids].
2001 Sep
Patents

Sample Use Guides

Unknown
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:00:50 GMT 2023
Edited
by admin
on Fri Dec 15 17:00:50 GMT 2023
Record UNII
NTZ53GG7XN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CODEINE HYDROCHLORIDE
MART.  
Common Name English
CODEINE HYDROCHLORIDE DIHYDRATE
EP  
Common Name English
MORPHINAN-6-OL, 7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, HYDROCHLORIDE, DIHYDRATE, (5.ALPHA.,6.ALPHA.)-
Systematic Name English
CODEINE HYDROCHLORIDE DIHYDRATE [EP IMPURITY]
Common Name English
CODEINE HCL
Common Name English
CODEINE HYDROCHLORIDE DIHYDRATE [EP MONOGRAPH]
Common Name English
Classification Tree Code System Code
DEA NO. 9050
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
Code System Code Type Description
FDA UNII
NTZ53GG7XN
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
DRUG BANK
DBSALT001068
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
WIKIPEDIA
Codeine hydrochloride
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EPA CompTox
DTXSID10207886
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EVMPD
SUB01405MIG
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
RXCUI
1115966
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY RxNorm
PUBCHEM
44146477
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EVMPD
SUB11840MIG
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
CAS
5916-29-0
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
SMS_ID
100000076636
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
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Related Record Type Details
ACTIVE MOIETY