U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3.ClH.2H2O
Molecular Weight 371.856
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CODEINE HYDROCHLORIDE

SMILES

O.O.Cl.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC

InChI

InChIKey=AWFZELCPUGEQGQ-NLMNJOOOSA-N
InChI=1S/C18H21NO3.ClH.2H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;;;/h3-6,11-13,17,20H,7-9H2,1-2H3;1H;2*1H2/t11-,12+,13-,17-,18-;;;/m0.../s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H21NO3
Molecular Weight 299.3642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
6.1 µM [EC50]
Target ID: P41145
Gene ID: 4986.0
Gene Symbol: OPRK1
Target Organism: Homo sapiens (Human)
Target ID: P41143
Gene ID: 4985.0
Gene Symbol: OPRD1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CAPITAL AND CODEINE

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Over-the-counter medications for acute cough in children and adults in ambulatory settings.
2001
Dystonia as acute adverse reaction to cough suppressant in a 3-year-old girl.
2001
[Pharmacokinetic and toxicokinetic parameters of some drugs of abuse].
2001
[Guillain-Barre syndrome as a result of poisoning with a mixture of "kompot"(Polish heroin) and drugs].
2001
Determination of opiates in serum, saliva and hair addicted persons.
2001
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis.
2001
Angle closure risk from proprietary medicines.
2001 Apr
Prescribing limitations.
2001 Aug 11
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
2001 Feb
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
2001 Jan
Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.
2001 Jul
Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine.
2001 Jul 27
Use of beta-cyclodextrin in the capillary zone electrophoretic separation of the components of clandestine heroin preparations.
2001 Jul 27
Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review.
2001 Jul 7
Heroin use by motorists in Sweden confirmed by analysis of 6-acetylmorphine in urine.
2001 Jul-Aug
Laboratory analysis of remotely collected oral fluid specimens for opiates by immunoassay.
2001 Jul-Aug
[Chronic pain in geriatrics].
2001 Jun
Myth: codeine is a powerful and effective analgesic.
2001 Jun
Ulcerated hemangiomas: clinical characteristics and response to therapy.
2001 Jun
[Information on preparations containing codeine].
2001 Jun 20
Codeine phosphate in children: time for re-evaluation?
2001 Mar
GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase extraction cartridges.
2001 Mar
Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.
2001 Mar
Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.
2001 Mar
Audit of pain management at home following tonsillectomy in children.
2001 Mar
Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAID's: a randomised study comparing analgesia, antinociception and gastrointestinal effects.
2001 Mar
Evaluation of urinary dihydrocodeine excretion in human by gas chromatography-mass spectrometry.
2001 Mar 5
Dextromethorphan is an effective cough suppressant.
2001 May
Dihydrocodeine--drug of use or misuse?
2001 May
The analgesic effect of codeine as compared to imipramine in different human experimental pain models.
2001 May
[Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary].
2001 May 13
Scalp nerve blocks decrease the severity of pain after craniotomy.
2001 Nov
Nutritional effects of surgical and medical treatment for short bowel syndrome.
2001 Nov-Dec
Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes.
2001 Oct
Analysis of morphine and codeine in samples adulterated with Stealth.
2001 Oct
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
2001 Oct
Predictors for completing an inpatient detoxification program among intravenous heroin users, methadone substituted and codeine substituted patients.
2001 Oct 1
Endogenous morphine and codeine. Possible role as endogenous anticonvulsants.
2001 Oct 12
Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999.
2001 Sep
Community pharmacists' experience of over-the-counter medicine misuse in Scotland.
2001 Sep
Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study.
2001 Sep
Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial.
2001 Sep
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
2001 Sep
Blind trials of an onsite saliva drug test for marijuana and opiates.
2001 Sep
[Strong opioids].
2001 Sep
Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
2001 Sep
Pain control in medical abortion.
2001 Sep
Engineering novel biocatalytic routes for production of semisynthetic opiate drugs.
2001 Sep
Can standard open pediatric urological procedures be performed on an outpatient basis?
2001 Sep
Experience with urine drug testing by the Correctional Service of Canada.
2001 Sep 15
Patents

Sample Use Guides

Unknown
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:00:50 GMT 2023
Edited
by admin
on Fri Dec 15 17:00:50 GMT 2023
Record UNII
NTZ53GG7XN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CODEINE HYDROCHLORIDE
MART.  
Common Name English
CODEINE HYDROCHLORIDE DIHYDRATE
EP  
Common Name English
MORPHINAN-6-OL, 7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, HYDROCHLORIDE, DIHYDRATE, (5.ALPHA.,6.ALPHA.)-
Systematic Name English
CODEINE HYDROCHLORIDE DIHYDRATE [EP IMPURITY]
Common Name English
CODEINE HCL
Common Name English
CODEINE HYDROCHLORIDE DIHYDRATE [EP MONOGRAPH]
Common Name English
Classification Tree Code System Code
DEA NO. 9050
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
Code System Code Type Description
FDA UNII
NTZ53GG7XN
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
DRUG BANK
DBSALT001068
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
WIKIPEDIA
Codeine hydrochloride
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EPA CompTox
DTXSID10207886
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EVMPD
SUB01405MIG
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
RXCUI
1115966
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY RxNorm
PUBCHEM
44146477
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
EVMPD
SUB11840MIG
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
CAS
5916-29-0
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
SMS_ID
100000076636
Created by admin on Fri Dec 15 17:00:50 GMT 2023 , Edited by admin on Fri Dec 15 17:00:50 GMT 2023
PRIMARY
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ACTIVE MOIETY