SAMERIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H34N2O
Molecular Weight	330.5075
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2

InChI

InChIKey=TYWUGCGYWNSRPS-UHFFFAOYSA-N

InChI=1S/C21H34N2O/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C21H34N2O
Molecular Weight	330.5075
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12538214 | https://www.ncbi.nlm.nih.gov/pubmed/9689276 | https://adisinsight.springer.com/drugs/800005282

Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Twenty-four healthy volunteers received either 25 mg of sameridine or 15 mg of bupivacaine intrathecally. Ventilation was measured by pneumotachography and in-line capnography

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:01:31 GMT 2023` Edited by `admin` on `Fri Dec 15 16:01:31 GMT 2023`
Record UNII	NQP2Y50Y6B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAMERIDINE

Official Name

English

sameridine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241