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Details

Stereochemistry ACHIRAL
Molecular Formula C21H34N2O
Molecular Weight 330.5075
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SAMERIDINE

SMILES

CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2

InChI

InChIKey=TYWUGCGYWNSRPS-UHFFFAOYSA-N
InChI=1S/C21H34N2O/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C21H34N2O
Molecular Weight 330.5075
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of sameridine in blood plasma by nitrogen-selective gas chromatography.
2001 Aug 25
Novel local anaesthetics and novel indications for local anaesthetics.
2001 Dec
The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo.
2001 Feb
Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine.
2003 Feb
Patents

Sample Use Guides

Twenty-four healthy volunteers received either 25 mg of sameridine or 15 mg of bupivacaine intrathecally. Ventilation was measured by pneumotachography and in-line capnography
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:01:31 UTC 2023
Edited
by admin
on Fri Dec 15 16:01:31 UTC 2023
Record UNII
NQP2Y50Y6B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SAMERIDINE
INN  
INN  
Official Name English
sameridine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C241
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
NCI_THESAURUS C1506
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID30162367
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
NCI_THESAURUS
C72174
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104504
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
WIKIPEDIA
SAMERIDINE
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
FDA UNII
NQP2Y50Y6B
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
CAS
143257-97-0
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
EVMPD
SUB10436MIG
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
SMS_ID
100000080549
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
INN
7050
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
MESH
C113809
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
PUBCHEM
65996
Created by admin on Fri Dec 15 16:01:31 UTC 2023 , Edited by admin on Fri Dec 15 16:01:31 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET->PARTIAL AGONIST
Related Record Type Details
ACTIVE MOIETY