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Details

Stereochemistry ACHIRAL
Molecular Formula C21H34N2O.ClH
Molecular Weight 366.968
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SAMERIDINE HYDROCHLORIDE

SMILES

Cl.CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2

InChI

InChIKey=VFXXNIHMKMOIQN-UHFFFAOYSA-N
InChI=1S/C21H34N2O.ClH/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19;/h8-10,12-13H,4-7,11,14-18H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C21H34N2O
Molecular Weight 330.5075
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of sameridine in blood plasma by nitrogen-selective gas chromatography.
2001 Aug 25
Novel local anaesthetics and novel indications for local anaesthetics.
2001 Dec
The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo.
2001 Feb
Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine.
2003 Feb
Patents

Sample Use Guides

Twenty-four healthy volunteers received either 25 mg of sameridine or 15 mg of bupivacaine intrathecally. Ventilation was measured by pneumotachography and in-line capnography
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:47:09 UTC 2023
Edited
by admin
on Sat Dec 16 14:47:09 UTC 2023
Record UNII
V3TSQ43P49
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SAMERIDINE HYDROCHLORIDE
Common Name English
4-PIPERIDINECARBOXAMIDE, N-ETHYL-1-HEXYL-N-METHYL-4-PHENYL-, MONOHYDROCHLORIDE
Systematic Name English
NIH 10908
Code English
Code System Code Type Description
FDA UNII
V3TSQ43P49
Created by admin on Sat Dec 16 14:47:09 UTC 2023 , Edited by admin on Sat Dec 16 14:47:09 UTC 2023
PRIMARY
PUBCHEM
9842135
Created by admin on Sat Dec 16 14:47:09 UTC 2023 , Edited by admin on Sat Dec 16 14:47:09 UTC 2023
PRIMARY
CAS
136483-84-6
Created by admin on Sat Dec 16 14:47:09 UTC 2023 , Edited by admin on Sat Dec 16 14:47:09 UTC 2023
PRIMARY
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