Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H34N2O.ClH |
| Molecular Weight | 366.968 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCCCCN1CCC(CC1)(C(=O)N(C)CC)C2=CC=CC=C2
InChI
InChIKey=VFXXNIHMKMOIQN-UHFFFAOYSA-N
InChI=1S/C21H34N2O.ClH/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19;/h8-10,12-13H,4-7,11,14-18H2,1-3H3;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C21H34N2O |
| Molecular Weight | 330.5075 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sameridine was developed as a compound with both local anesthetic and opioid properties (partial micro-opioid receptor agonist). This drug participated in clinical trials when administered intrathecally to provide anesthesia for surgery and extended postoperative analgesia. However, further development of this drug was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Determination of sameridine in blood plasma by nitrogen-selective gas chromatography. | 2001 Aug 25 |
|
| Novel local anaesthetics and novel indications for local anaesthetics. | 2001 Dec |
|
| The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo. | 2001 Feb |
|
| Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine. | 2003 Feb |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:47:09 GMT 2023
by
admin
on
Sat Dec 16 14:47:09 GMT 2023
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| Record UNII |
V3TSQ43P49
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| Record Status |
Validated (UNII)
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| Record Version |
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V3TSQ43P49
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9842135
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136483-84-6
Created by
admin on Sat Dec 16 14:47:09 GMT 2023 , Edited by admin on Sat Dec 16 14:47:09 GMT 2023
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PARENT -> SALT/SOLVATE |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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