U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C4H9N3O2
Molecular Weight 131.1332
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CREATINE

SMILES

CN(CC(O)=O)C(N)=N

InChI

InChIKey=CVSVTCORWBXHQV-UHFFFAOYSA-N
InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

HIDE SMILES / InChI

Molecular Formula C4H9N3O2
Molecular Weight 131.1332
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Creatine is an amino acid that occurs in vertebrate tissues and in urine. It is synthesized mainly in the liver from three different amino acids: arginine, glycine, and methionine. In skeletal muscles, which store 95% of it, creatine generally occurs as phosphocreatine. The rest is stored in the brain, heart, and testes. Creatine functions as part of the cell's energy shuttle. It is excreted as creatinine in the urine.

Approval Year

PubMed

PubMed

TitleDatePubMed
Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder.
2001 Apr
Neuroprotective effects of MK-801 on L-2-chloropropionic acid-induced neurotoxicity.
2001 Feb
Parkinsonism and neck extensor myopathy: a new syndrome or coincidental findings?
2001 Feb
Thrombectomy with the X-SIZER catheter system in the coronary circulation: initial results from a multi-center study.
2001 Feb
Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats.
2001 Feb
Cardiac troponins and creatine kinase content of striated muscle in common laboratory animals.
2001 Feb
Reproducibility of hippocampal single-Voxel proton MR spectroscopy and chemical shift imaging.
2001 Feb
Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning.
2001 Feb
Myopathic form of very-long chain acyl-coa dehydrogenase deficiency: evidence for temperature-sensitive mild mutations in both mutant alleles in a Japanese girl.
2001 Feb
Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study.
2001 Feb
Safe discharge from the cardiac emergency room with a rapid rule-out myocardial infarction protocol using serial CK-MB(mass).
2001 Feb
Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1.
2001 Feb 1
Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation.
2001 Feb 2
The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip.
2001 Feb 2
Deterioration in renal function associated with fibrate therapy.
2001 Jan
Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin.
2001 Jan
Exercise training increases creatine kinase capacity in canine myocardium.
2001 Jan
Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors.
2001 Jan
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury.
2001 Jan
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.
2001 Jan
Improving diagnostic yield in brain biopsy: coupling spectroscopic targeting with real-time needle placement.
2001 Jan
Plasma lipids and urinary albumin excretion rate in Type 1 diabetes mellitus: the EURODIAB IDDM Complications Study.
2001 Jan
Recovery of muscles of old rats after hindlimb immobilisation by external fixation is impaired compared with those of young rats.
2001 Jan
Proton MR spectroscopy in patients with acute temporal lobe seizures.
2001 Jan
Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury.
2001 Jan
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
2001 Jan
Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas.
2001 Jan
Temporal lobe epilepsy: qualitative reading of 1H MR spectroscopic images for presurgical evaluation.
2001 Jan
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities.
2001 Jan
Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization.
2001 Jan
Effect of abciximab on cardiac enzyme elevation after transluminal extraction atherectomy (TEC) in high-risk saphenous vein graft lesions: comparison with a historical control group.
2001 Jan
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.
2001 Jan
Protein kinase C isoform-dependent myocardial protection by ischemic preconditioning and potassium cardioplegia.
2001 Jan
Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis.
2001 Jan
Varicella myocarditis in an adult.
2001 Jan
A genome scan for renal function among hypertensives: the HyperGEN study.
2001 Jan
Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease.
2001 Jan
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
2001 Jan 1
An autopsy case of neuroleptic malignant syndrome (NMS) and its immunohistochemical findings of muscle-associated proteins and mitochondria.
2001 Jan 1
Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies.
2001 Jan 20
Expression and purification of polyhistidine-tagged firefly luciferase in insect cells--a potential alternative for process scale-up.
2001 Jan 23
Myotoxicity studies of injectable biodegradable in-situ forming drug delivery systems.
2001 Jan 5
Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction.
2001 Jan 6
Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma.
2001 Mar
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:31 GMT 2023
Edited
by admin
on Fri Dec 15 15:00:31 GMT 2023
Record UNII
MU72812GK0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CREATINE
HSDB   II   INCI   MI   VANDF   WHO-DD  
INCI  
Official Name English
COSMOCAIR C 100
Common Name English
CREATINE [VANDF]
Common Name English
(N-(AMIDINO)-N-METHYLAMINO)ACETIC ACID
Systematic Name English
NSC-8752
Code English
CREATINE [USP-RS]
Common Name English
(.ALPHA.-METHYLGUANIDO)ACETIC ACID
Common Name English
GLYCINE, N-(AMINOIMINOMETHYL)-N-METHYL-
Systematic Name English
Creatine [WHO-DD]
Common Name English
NEOTINE
Common Name English
CREATINE [MI]
Common Name English
CREATINE [HSDB]
Common Name English
KREATINUM
Common Name English
CREATINE [II]
Common Name English
N-AMIDINOSARCOSINE
Systematic Name English
N-(AMINOIMINOMETHYL)-N-METHYLGLYCINE
Systematic Name English
CREATINE [INCI]
Common Name English
N-METHYL-N-GUANYLGLYCINE
Systematic Name English
METHYLGLYCOCYAMINE
Systematic Name English
Classification Tree Code System Code
LOINC 53074-1
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 15046-6
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LOINC 33797-2
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LOINC 15045-8
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LOINC 16687-6
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
FDA ORPHAN DRUG 210005
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 49097-9
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 2148-5
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CFR 21 CFR 862.1210
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 2150-1
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LOINC 13484-1
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LOINC 15047-4
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
NCI_THESAURUS C73539
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
DSLD 397 (Number of products:1912)
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 44418-2
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LOINC 56645-5
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LOINC 3123-7
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LOINC 34274-1
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FDA ORPHAN DRUG 152701
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 53055-0
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
LOINC 34275-8
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LOINC 2149-3
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
Code System Code Type Description
CHEBI
57947
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
FDA UNII
MU72812GK0
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
CHEBI
16919
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
MERCK INDEX
m3826
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C37937
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
SMS_ID
100000079856
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
CAS
57-00-1
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
RXCUI
2907
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY RxNorm
DAILYMED
MU72812GK0
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
MESH
D003401
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
WIKIPEDIA
CREATINE
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
EPA CompTox
DTXSID1040451
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
PUBCHEM
586
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
DRUG BANK
DB00148
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
NSC
8752
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
RS_ITEM_NUM
1150320
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-306-6
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
HSDB
7336
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
DRUG CENTRAL
4661
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
EVMPD
SUB13486MIG
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
LACTMED
Creatine
Created by admin on Fri Dec 15 15:00:31 GMT 2023 , Edited by admin on Fri Dec 15 15:00:31 GMT 2023
PRIMARY
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