PIMIVALIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:52:07 GMT 2025` Edited by `admin` on `Tue Apr 01 22:52:07 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	MA05AF40UO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIMIVALIMAB

Official Name

English

pimivalimab [INN]

Preferred Name

English

PIMIVALIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G4 (226-PROLINE,C-TERMINAL-LYSINE-CLIPPED), ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN MONOCLONAL JTX-4014 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JTX-4014 .KAPPA.-CHAIN, DIMER

Common Name

English

JTX-4014

Code

English

Pimivalimab [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1; CD274 ANTIGEN)); HUMAN MONOCLONAL ANTIBODY; .GAMMA.4 HEAVY CHAIN HOMO SAPIENS (1-444) (VH HOMO SAPIENS (IGHV1-46*01 (97%) (IGHD)-IGHJ5*02) (8.8.11) (1-118)-HOMO SAPIENS

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C157485

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

CAS

2245092-16-2

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

NO STRUCTURE GIVEN

FDA UNII

MA05AF40UO

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

USAN

JK-140

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

INN

11461

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

SMS_ID

300000015483

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

CAS

2293951-22-9

Created by admin on Tue Apr 01 22:52:07 GMT 2025 , Edited by admin on Tue Apr 01 22:52:07 GMT 2025

PRIMARY

From	To
1_22	1_96
1_132	1_145
1_201	3_214
1_224	2_224
1_227	2_227
1_259	1_319
1_365	1_423
2_22	2_96
2_132	2_145
2_201	4_214
2_259	2_319
2_365	2_423
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Link Type	Site
N	1_295
N	2_295

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					MA05AF40UO

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_445] [2_445]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL