Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 13:18:48 GMT 2023
by
admin
on
Sat Dec 16 13:18:48 GMT 2023
|
| Protein Type | RECEPTOR |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
938DNF64FO
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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938DNF64FO
Created by
admin on Sat Dec 16 13:18:49 GMT 2023 , Edited by admin on Sat Dec 16 13:18:49 GMT 2023
|
PRIMARY | |||
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PROGRAMMED CELL DEATH PROTEIN 1
Created by
admin on Sat Dec 16 13:18:49 GMT 2023 , Edited by admin on Sat Dec 16 13:18:49 GMT 2023
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PRIMARY | |||
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Q15116
Created by
admin on Sat Dec 16 13:18:49 GMT 2023 , Edited by admin on Sat Dec 16 13:18:49 GMT 2023
|
PRIMARY | |||
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5133
Created by
admin on Sat Dec 16 13:18:49 GMT 2023 , Edited by admin on Sat Dec 16 13:18:49 GMT 2023
|
PRIMARY | |||
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938DNF64FO
Created by
admin on Sat Dec 16 13:18:49 GMT 2023 , Edited by admin on Sat Dec 16 13:18:49 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_34 | 1_103 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_29 |
| N | 1_38 |
| N | 1_54 |
| N | 1_96 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET | |||
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LIGAND->TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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LIGAND->TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
knockdown of PD-1 (≥33.7%)
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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AGONIST -> TARGET |
PD-L2 binds to its receptor PD-1 with dissociation constant Kd of 11.3 nM.[16] Binding to PD-1 can activate pathways inhibiting TCR/BCR-mediated immune cell activation
BINDING
Kd
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Attenuate the inhibitory signals of CTLA-4 and PD-1 on T cells.
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INHIBITOR -> TARGET |
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LIGAND->TARGET |
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LIGAND->TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
(Biacore) Antigens were immobilized on a sensor chip, and varying concentrations of AK105 (1.56 to 50 nM) were flown over immobilized PD-1 at the flow rate of 30 μL/min.
BINDING
Kd
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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LIGAND->TARGET |
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INHIBITOR -> TARGET | |||
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LIGAND->TARGET |
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LIGAND->TARGET |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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