DICLAZURIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H9Cl3N4O2
Molecular Weight	407.638
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ClC1=CC=C(C=C1)C(C#N)C2=C(Cl)C=C(C=C2Cl)N3N=CC(=O)NC3=O

InChI

InChIKey=ZSZFUDFOPOMEET-UHFFFAOYSA-N

InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)

HIDE SMILES / InChI

Molecular Formula	C17H9Cl3N4O2
Molecular Weight	407.638
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Diclazuril is a main component of veterinary drugs used for the treatment of coccidiosis (chickens, turkeys, rabbits, etc) and equine protozoal myeloencephalitis (horses). When used for the treatment of coccidiosis, it acts by causing the degeneration of schizonts and gamonts. While in the animals affected by protozoal myeloencephalitis the drug is believed to inhibit merozoite production. In vivo experiments on horses have shown that the drug may cross the blood brain barrier.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Differentiation during parasite development 2	Inhibitor 8,504
Merozoite production 2	Inhibitor 8,504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45	Preventing		Approved 8,583	CLINACOX
Equine protozoal myeloencephalitis 3	Curative		Approved 8,583	PROTAZIL

PubMed

Show entries

Title	Date	PubMed
In vitro quantitative analysis of (3)H-uracil incorporation by Sarcocytis neurona to determine efficacy of anti-protozoal agents.	2001 Feb 26	11223204
Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts.	2001 Jan 20	11137273
Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry.	2004 Dec 25	15556532
Effects of a herbal complex against Eimeria tenella infection in chickens.	2004 May	15228556
Control of coccidiosis in turkeys with diclazuril and monensin: effects upon performance and development of immunity to Eimeria species.	2004 Sep	15529986

Showing 1 to 5 of 15 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Coccidiosis: Mix 200 gram of Clinacox 0.5% premix per ton of complete feed. Equine protozoal myeloencephalitis: 1 milligram per kilogram of body weight in the daily grain ration for 28 days

Route of Administration: Oral

In Vitro Use Guide

Unknown