Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H8Cl3N4O2.Na |
| Molecular Weight | 429.62 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].ClC1=CC=C(C=C1)C(C#N)C2=C(Cl)C=C(C=C2Cl)N3N=CC(=O)[N-]C3=O
InChI
InChIKey=HMGDHGGCYNUBOJ-UHFFFAOYSA-M
InChI=1S/C17H9Cl3N4O2.Na/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24;/h1-6,8,12H,(H,23,25,26);/q;+1/p-1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H9Cl3N4O2 |
| Molecular Weight | 407.638 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionCurator's Comment: description was created based on several sources, including, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a
Curator's Comment: description was created based on several sources, including, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a
Diclazuril is a main component of veterinary drugs used for the treatment of coccidiosis (chickens, turkeys, rabbits, etc) and equine protozoal myeloencephalitis (horses). When used for the treatment of coccidiosis, it acts by causing the degeneration of schizonts and gamonts. While in the animals affected by protozoal myeloencephalitis the drug is believed to inhibit merozoite production. In vivo experiments on horses have shown that the drug may cross the blood brain barrier.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Differentiation during parasite development |
|||
Target ID: Merozoite production |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | CLINACOX Approved UseFor the prevention of coccidiosis in animals. Launch Date9.2456642E11 |
|||
| Curative | PROTAZIL Approved UseFor the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Launch Date1.17504003E12 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs. | 1990 Aug |
|
| Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model. | 1993 Mar |
|
| Activity of toltrazuril and diclazuril against Isospora species in kittens and puppies. | 2001 Apr 21 |
|
| Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts. | 2001 Jan 20 |
|
| The use of diclazuril in extended withdrawal anticoccidial programs: 2. Immunity to Eimeria tenella challenge after drug withdrawal. | 2002 Mar |
|
| The effect of a metaphylactic treatment with diclazuril (Vecoxan) on the oocyst excretion and growth performance of calves exposed to a natural Eimeria infection. | 2007 Nov 10 |
|
| Comparison of three adjuvants used to produce polyclonal antibodies to veterinary drugs. | 2008 Mar 15 |
|
| Dietary supplementation of mannan-oligosaccharide enhances neonatal immune responses in chickens during natural exposure to Eimeria spp. | 2009 Mar 19 |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=141-268
Coccidiosis: Mix 200 gram of Clinacox 0.5% premix per ton of complete feed. Equine protozoal myeloencephalitis: 1 milligram per kilogram of body weight in the daily grain ration for 28 days
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:14:55 UTC 2023
by
admin
on
Sat Dec 16 11:14:55 UTC 2023
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| Record UNII |
5K4327702E
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| Record Status |
Validated (UNII)
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| Record Version |
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5K4327702E
Created by
admin on Sat Dec 16 11:14:56 UTC 2023 , Edited by admin on Sat Dec 16 11:14:56 UTC 2023
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59915424
Created by
admin on Sat Dec 16 11:14:56 UTC 2023 , Edited by admin on Sat Dec 16 11:14:56 UTC 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
