DICLAZURIL SODIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H8Cl3N4O2.Na
Molecular Weight	429.62
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].ClC1=CC=C(C=C1)C(C#N)C2=C(Cl)C=C(C=C2Cl)N3N=CC(=O)[N-]C3=O

InChI

InChIKey=HMGDHGGCYNUBOJ-UHFFFAOYSA-M

InChI=1S/C17H9Cl3N4O2.Na/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24;/h1-6,8,12H,(H,23,25,26);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H9Cl3N4O2
Molecular Weight	407.638
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.biovet.com/products/Anticoccidials/Clinacox.pdf
Curator's Comment: description was created based on several sources, including, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a

Diclazuril is a main component of veterinary drugs used for the treatment of coccidiosis (chickens, turkeys, rabbits, etc) and equine protozoal myeloencephalitis (horses). When used for the treatment of coccidiosis, it acts by causing the degeneration of schizonts and gamonts. While in the animals affected by protozoal myeloencephalitis the drug is believed to inhibit merozoite production. In vivo experiments on horses have shown that the drug may cross the blood brain barrier.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Differentiation during parasite development 2 Target ID: Differentiation during parasite development Sources: http://www.biovet.com/products/Anticoccidials/Clinacox.pdf	Inhibitor 8297
Merozoite production 2 Target ID: Merozoite production Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.biovet.com/products/Anticoccidials/Clinacox.pdf	Preventing		Approved 8429	CLINACOX Approved Use For the prevention of coccidiosis in animals. Launch Date 1999
Equine protozoal myeloencephalitis 3 Sources: https://merckusa.cvpservice.com/product/basic/view/1047490	Curative		Approved 8429	PROTAZIL Approved Use For the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Launch Date 2007

PubMed

Title	Date	PubMed
Activity of diclazuril against Toxoplasma gondii in cultured cells and mice.	1994 Apr	8017699
The use of diclazuril in extended withdrawal anticoccidial programs: 1. Efficacy against Eimeria spp. in broiler chickens in floor pens.	2002 Mar	11902410
Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001.	2003 Aug	17585463
Histopathological observations on the activity of diclazuril (Vecoxan) against the endogenous stages of Eimeria crandallis in sheep.	2003 Oct 30	14580801
Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry.	2004 Dec 25	15556532
Epidemiology of Eimeria infections in an Austrian milking sheep flock and control with diclazuril.	2005 Apr 20	15817196
Deposition and depletion of five anticoccidials in eggs.	2005 Sep 7	16131122
The efficacy and economic benefits of Supercox, a live anticoccidial vaccine in a commercial trial in broiler chickens in China.	2006 Nov 30	16876953
Higher incidence of Eimeria spp. field isolates sensitive for diclazuril and monensin associated with the use of live coccidiosis vaccination with paracox-5 in broiler farms.	2006 Sep	17039846
Efficacy of various anticoccidials against experimental porcine neonatal isosporosis.	2007 Jan	17048000
Use of antigen mimics to produce specific antibodies to anti-coccidial drugs.	2007 May 31	17433817
The effect of a metaphylactic treatment with diclazuril (Vecoxan) on the oocyst excretion and growth performance of calves exposed to a natural Eimeria infection.	2007 Nov 10	17850970
Comparison of three adjuvants used to produce polyclonal antibodies to veterinary drugs.	2008 Mar 15	18063100
Dietary supplementation of mannan-oligosaccharide enhances neonatal immune responses in chickens during natural exposure to Eimeria spp.	2009 Mar 19	19298670
Fast liquid chromatography/multiple-stage mass spectrometry of coccidiostats.	2009 May	19308967
Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry.	2009 Nov 13	19481216
Validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for 10 anticoccidials in eggs according to Commission Decision 2002/657/EC.	2009 Nov 13	19442981
Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.	2010 Jun	20198524
Histomorphometry and macroscopic intestinal lesions in broilers infected with Eimeria acervulina.	2010 Mar 25	20080348
Livestock drugs and disease: the fatal combination behind breeding failure in endangered bearded vultures.	2010 Nov 30	21152405

Patents

Sample Use Guides

In Vivo Use Guide

Coccidiosis: Mix 200 gram of Clinacox 0.5% premix per ton of complete feed. Equine protozoal myeloencephalitis: 1 milligram per kilogram of body weight in the daily grain ration for 28 days

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:14:55 GMT 2023` Edited by `admin` on `Sat Dec 16 11:14:55 GMT 2023`
Record UNII	5K4327702E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DICLAZURIL SODIUM

Common Name

English

BENZENEACETONITRILE, 2,6-DICHLORO-.ALPHA.-(4-CHLOROPHENYL)-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-YL)-, SODIUM SALT

Common Name

English

BENZENEACETONITRILE, 2,6-DICHLORO-.ALPHA.-(4-CHLOROPHENYL)-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-YL)-, SODIUM SALT (1:1)

Systematic Name

English

SODIUM DICLAZURIL

Common Name

English

Code System Code Type Description

CAS

112209-99-1

Created by admin on Sat Dec 16 11:14:56 GMT 2023 , Edited by admin on Sat Dec 16 11:14:56 GMT 2023

PRIMARY

FDA UNII

5K4327702E

Created by admin on Sat Dec 16 11:14:56 GMT 2023 , Edited by admin on Sat Dec 16 11:14:56 GMT 2023

PRIMARY

PUBCHEM

59915424

Created by admin on Sat Dec 16 11:14:56 GMT 2023 , Edited by admin on Sat Dec 16 11:14:56 GMT 2023

PRIMARY

Related Record Type Details


					K110K1B1VE

DICLAZURIL

PARENT -> SALT/SOLVATE

Details

SMILES

InChI

DescriptionSources: http://www.biovet.com/products/Anticoccidials/Clinacox.pdfCurator's Comment: description was created based on several sources, including, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a

CNS Activity

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Launch Date

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.biovet.com/products/Anticoccidials/Clinacox.pdf
Curator's Comment: description was created based on several sources, including, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=875c461a-e0db-4478-9006-7bd1d006ed3a