Corticotropin

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/008372s057lbl.pdf | https://www.drugbank.ca/drugs/DB01285

Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland. Corticotropin acts through the stimulation of cell surface the adrenocorticotropic hormone (ACTH) receptors, which are primarily located on the adrenocortical cells. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). Corticotropin is indicated as monotherapy for the treatment of exacerbations of multiple sclerosis in adults and infantile spasms in infants and children under 2 years of age. Controlled clinical trials have shown Corticotropin to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease. The mechanism of action of Corticotropin in the treatment of infantile spasms is unknown.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Multiple sclerosis 104 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022432s000lbl.pdf	Primary		Approved 8429	ACTHAR Approved Use H.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date 1950
infantile spasm 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022432s000lbl.pdf	Primary		Approved 8429	ACTHAR Approved Use H.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date 1950

PubMed

Title	Date	PubMed




[SYNDROME OF INTRACRANIAL HYPERTENSION CAUSED BY TREATMENT WITH CORTICOTROPIN].	1964 Jan 31	14124206
Complications of corticotropin therapy in multiple sclerosis.	1966 Jul 18	15214377
Some observations on the hazards of corticosteroid therapy in patients with inflammatory bowel disease.	1967 Mar-Apr	4292814
[Neuropsychiatric complications caused by cortisone and ACTH. (Clinico-social considerations)].	1968 Apr-Jun	4327030
Steroid myopathy complicating McArdle's disease.	1970 Feb	4313853
Reversible cerebral atrophy and corticotrophin.	1979 Jul 28	89327
Transient brain shrinkage in infantile spasms after ACTH treatment. Report of two cases.	1980 Feb	6258109
Cerebral atrophy following ACTH therapy.	1980 Feb	6243678
Aicardi's syndrome: are corticosteroids teratogens?	1981 Jan	6257213
[Collateral transient behavioural changes during ACTH therapy in infantile generalized epilepsy (author's transl)].	1981 Mar-Jun	6283484
Sequential CT studies of 24 children with infantile spasms on ACTH therapy.	1983 Aug	6311654
'Dystonia'-like postural asymmetry after microinjection of ACTH N-terminal fragments but not after ACTH1-39 in rat brainstem suggests role of neuropeptide mutation in genetic movement disorder.	1984 Feb 27	6320978
Acute-onset transient hydrocephalus after suspension of ACTH therapy for infantile spasms: a case report.	1984 Jun	6088422
Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms.	1985	3008584
Cerebral blood flow and brain shrinkage seen on CT during ACTH therapy.	1986	3030155
Administration of ACTH to suckling rats results in hyperkinetic behavior.	1986	3030154
[Long-term prognosis of infantile spasms after standard ACTH treatment in Japan].	1986 Sep	3019372
A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.	1988	2840807
ACTH and vasopressin responses to insulin-induced hypoglycemia in intact and neurohypophysectomized conscious dogs.	1991 Jan	1646414
Infantile spasms in COFS syndrome.	1991 Jul-Aug	1930425
Magnetic resonance imaging in infantile spasms: effects of hormonal therapy.	1992 Mar-Apr	1312459
Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32.	1999 Sep	10516482
Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.	2003 Apr	12639925
Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.	2003 Jul	12832253
Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure.	2005 Dec 6	16330704
Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause.	2006 Apr	16647410
Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate-limiting steps in steroidogenesis.	2006 Apr	16410306
Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats.	2006 Jan 4	16330021
Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.	2007 Oct 15	17716631
Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA.	2008 Feb	18239281
Long-term weekly ACTH therapy for relapsed West syndrome.	2008 Jun	18486831
Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors?	2008 May	18255130
Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature.	2009	18176844
The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells.	2009 Jan 8	18835572

Sample Use Guides

In Vivo Use Guide

The usual dose of Corticotropin is 40-80 units given intramuscularly or subcutaneously every 24-72 hours.

Route of Administration: Other

Substance Class	Protein Created by `admin` on `Sat Dec 16 00:29:52 GMT 2023` Edited by `admin` on `Sat Dec 16 00:29:52 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	K0U68Q2TXA
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

Corticotropin

Official Name

English

CORTROPHIN

Brand Name

English

CORTICOTROPIN [ORANGE BOOK]

Common Name

English

ADRENOCORTICOTROPHIN

Common Name

English

CORTICOTROPIN [USP-RS]

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English

25-ASP-30-GLN-CORTICOTROPIN PORCINE

Common Name

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ACTH [MI]

Common Name

English

CORTICOTROPIN [VANDF]

Common Name

English

CORTICOTROPIN (ACTH)

Common Name

English

ACTHAR

Brand Name

English

ACTH	Locators: MI Sources:

Brand Name

English

CORTICOTROPHIN

Common Name

English

CORTICOTROPIN [USP IMPURITY]

Common Name

English

ADRENOCORTICOTROPIC HORMONE

Common Name

English

corticotropin [INN]

Common Name

English

Corticotropin [WHO-DD]

Common Name

English

CORTICOTROPIN [GREEN BOOK]

Common Name

English

ADRENOCORTICOTROPHIN [HPUS]

Common Name

English

PURIFIED CORTROPHIN GEL

Brand Name

English

.ALPHA.1-39-CORTICOTROPIN (SWINE), 25-L-ASPARTIC ACID-30-L-GLUTAMINE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 862.1025