Corticotropin zinc hydroxide

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/008372s057lbl.pdf | https://www.drugbank.ca/drugs/DB01285

Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland. Corticotropin acts through the stimulation of cell surface the adrenocorticotropic hormone (ACTH) receptors, which are primarily located on the adrenocortical cells. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). Corticotropin is indicated as monotherapy for the treatment of exacerbations of multiple sclerosis in adults and infantile spasms in infants and children under 2 years of age. Controlled clinical trials have shown Corticotropin to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease. The mechanism of action of Corticotropin in the treatment of infantile spasms is unknown.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Multiple sclerosis 107 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022432s000lbl.pdf	Primary		Approved 8583	ACTHAR Approved Use H.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date 1950
infantile spasm 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022432s000lbl.pdf	Primary		Approved 8583	ACTHAR Approved Use H.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date 1950

PubMed

Title	Date	PubMed
The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells.	2009-01-08	18835572
Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature.	2009	18176844
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.	2008-07	18645707
Long-term weekly ACTH therapy for relapsed West syndrome.	2008-06	18486831
Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors?	2008-05	18255130
Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA.	2008-02	18239281
Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.	2007-10-15	17716631
Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause.	2006-04	16647410
Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate-limiting steps in steroidogenesis.	2006-04	16410306
Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats.	2006-01-04	16330021
Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure.	2005-12-06	16330704
Nelson's syndrome due to an intracavernous corticotropin-secreting adenoma.	2004-07-15	15251683
Inhibition of CYP17 expression by adrenal androgens and transforming growth factor beta in adrenocortical cells.	2004	15625562
Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.	2003-07	12832253
Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.	2003-04	12639925
Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32.	1999-09	10516482
Activity of adenosine deaminase in red blood cells of patients suffering from multiple sclerosis treated with adrenocorticotropic hormone.	1995-11-01	8868375
Magnetic resonance imaging in infantile spasms: effects of hormonal therapy.	1992-03-01	1312459
Infantile spasms in COFS syndrome.	1991-07-01	1930425
ACTH and vasopressin responses to insulin-induced hypoglycemia in intact and neurohypophysectomized conscious dogs.	1991-01	1646414
A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.	1988	2840807
[Long-term prognosis of infantile spasms after standard ACTH treatment in Japan].	1986-09	3019372
Cerebral blood flow and brain shrinkage seen on CT during ACTH therapy.	1986	3030155
Administration of ACTH to suckling rats results in hyperkinetic behavior.	1986	3030154
Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms.	1985	3008584
Acute-onset transient hydrocephalus after suspension of ACTH therapy for infantile spasms: a case report.	1984-06	6088422
'Dystonia'-like postural asymmetry after microinjection of ACTH N-terminal fragments but not after ACTH1-39 in rat brainstem suggests role of neuropeptide mutation in genetic movement disorder.	1984-02-27	6320978
Sequential CT studies of 24 children with infantile spasms on ACTH therapy.	1983-08	6311654
[Collateral transient behavioural changes during ACTH therapy in infantile generalized epilepsy (author's transl)].	1981-03-01	6283484
Aicardi's syndrome: are corticosteroids teratogens?	1981-01	6257213
Transient brain shrinkage in infantile spasms after ACTH treatment. Report of two cases.	1980-02	6258109
Cerebral atrophy following ACTH therapy.	1980-02	6243678
Reversible cerebral atrophy and corticotrophin.	1979-07-28	89327
Steroid myopathy complicating McArdle's disease.	1970-02	4313853
[Neuropsychiatric complications caused by cortisone and ACTH. (Clinico-social considerations)].	1968-04-01	4327030
Some observations on the hazards of corticosteroid therapy in patients with inflammatory bowel disease.	1967-03-01	4292814
Complications of corticotropin therapy in multiple sclerosis.	1966-07-18	15214377
[SYNDROME OF INTRACRANIAL HYPERTENSION CAUSED BY TREATMENT WITH CORTICOTROPIN].	1964-01-31	14124206

Sample Use Guides

In Vivo Use Guide

The usual dose of Corticotropin is 40-80 units given intramuscularly or subcutaneously every 24-72 hours.

Route of Administration: Other

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:52:36 GMT 2025` Edited by `admin` on `Tue Apr 01 19:52:36 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	L0378Q1565
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CORTICOTROPIN-ZINC HYDROXIDE

Preferred Name

English

Corticotropin zinc hydroxide

Official Name

English

corticotropin zinc hydroxide [INN]

Common Name

English

CORTICOTROPIN-ZINC HYDROXIDE [ORANGE BOOK]

Common Name

English

Corticotropin zinc hydroxide [WHO-DD]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID60238185