U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 15:10:53 GMT 2023
Edited
by admin
on Sat Dec 16 15:10:53 GMT 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvoviridae
Organism Genus Dependovirus
Organism Species adeno-associated virus
Infraspecific Type SUBSTRAIN
Infraspecific Name adeno-associated virus type 2/6 (rAAV Rep2-Cap6) vector, which contains a promoterless human coagulation factor IX (hF9, Factor IX or FIX) transgene cassette
Part WHOLE
Record UNII
J177M7U2XK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADLINACOGENE CIVAPARVOVEC
INN  
Official Name English
SB-FIX
Common Name English
adlinacogene civaparvovec [INN]
Common Name English
A RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRUS TYPE 2/6 (RAAV REP2-CAP6) VECTOR, WHICH CONTAINS A PROMOTERLESS HUMAN COAGULATION FACTOR IX (HF9, FACTOR IX OR FIX) TRANSGENE CASSETTE, ENCODING EXONS 2-8 AND SPLICE ACCEPTOR SITE SEQUENCE (SA) FROM HF
Systematic Name English
Code System Code Type Description
INN
10978
Created by admin on Sat Dec 16 15:10:53 GMT 2023 , Edited by admin on Sat Dec 16 15:10:53 GMT 2023
PRIMARY
CAS
2143579-02-4
Created by admin on Sat Dec 16 15:10:53 GMT 2023 , Edited by admin on Sat Dec 16 15:10:53 GMT 2023
PRIMARY
NCI_THESAURUS
C171790
Created by admin on Sat Dec 16 15:10:53 GMT 2023 , Edited by admin on Sat Dec 16 15:10:53 GMT 2023
PRIMARY
FDA UNII
J177M7U2XK
Created by admin on Sat Dec 16 15:10:53 GMT 2023 , Edited by admin on Sat Dec 16 15:10:53 GMT 2023
PRIMARY
Related Record Type Details
INNOVATOR->PARENT
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
TRANSGENE ADLINACOGENE CIVAPARVOVEC TRANSGENE INSERT UM90H33QOQ