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Details

Stereochemistry ABSOLUTE
Molecular Formula C9H19N
Molecular Weight 141.2539
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXISOMETHEPTENE

SMILES

CN[C@H](C)CCC=C(C)C

InChI

InChIKey=XVQUOJBERHHONY-SECBINFHSA-N
InChI=1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3/t9-/m1/s1

HIDE SMILES / InChI

Molecular Formula C9H19N
Molecular Weight 141.2539
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

ISOMETHEPTENE, (R)- is an antimigraine drug candidate, which development was discontinued in 2016. It is a potent agonist of the imidazoline-1-receptor.

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats.
2017 Dec
Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery - potential antimigraine efficacy.
2019 May 3
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:22:12 GMT 2023
Edited
by admin
on Sat Dec 16 11:22:12 GMT 2023
Record UNII
GOO8ZCK7RT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEXISOMETHEPTENE
INN   USAN  
USAN   INN  
Official Name English
ISOMETHEPTENE, (R)-
Common Name English
5-HEPTEN-2-AMINE, N,6-DIMETHYL-, (2R)-
Systematic Name English
dexisometheptene [INN]
Common Name English
TNX-200
Code English
DEXISOMETHEPTENE [USAN]
Common Name English
(R)-ISOMETHEPTENE
Common Name English
(2R)-N,6-DIMETHYLHEPT-5-EN-2-AMINE ANTIMIGRAINE
Systematic Name English
Code System Code Type Description
PUBCHEM
24871315
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
FDA UNII
GOO8ZCK7RT
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
INN
10309
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
CAS
1620401-56-0
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
USAN
CD-108
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
NCI_THESAURUS
C169896
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
SMS_ID
100000174625
Created by admin on Sat Dec 16 11:22:13 GMT 2023 , Edited by admin on Sat Dec 16 11:22:13 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SALT/SOLVATE -> PARENT
RACEMATE -> ENANTIOMER
Related Record Type Details
ACTIVE MOIETY