DEXISOMETHEPTENE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H19N
Molecular Weight	141.2539
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN[C@H](C)CCC=C(C)C

InChI

InChIKey=XVQUOJBERHHONY-SECBINFHSA-N

InChI=1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3/t9-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C9H19N
Molecular Weight	141.2539
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28474252 | https://finance.yahoo.com/news/tnxp-tnx-201-development-stopped-184500374.html

ISOMETHEPTENE, (R)- is an antimigraine drug candidate, which development was discontinued in 2016. It is a potent agonist of the imidazoline-1-receptor.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats.	2017 Dec	28474252
Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery - potential antimigraine efficacy.	2019 May 3	31053059

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:22:12 GMT 2023` Edited by `admin` on `Sat Dec 16 11:22:12 GMT 2023`
Record UNII	GOO8ZCK7RT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXISOMETHEPTENE

Official Name

English

ISOMETHEPTENE, (R)-

Common Name

English

5-HEPTEN-2-AMINE, N,6-DIMETHYL-, (2R)-

Systematic Name

English

dexisometheptene [INN]

Common Name

English

TNX-200

Code

English

DEXISOMETHEPTENE [USAN]

Common Name

English

(R)-ISOMETHEPTENE

Common Name

English

(2R)-N,6-DIMETHYLHEPT-5-EN-2-AMINE ANTIMIGRAINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

24871315