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Details

Stereochemistry ACHIRAL
Molecular Formula C16H17ClN2O
Molecular Weight 288.772
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TETRAZEPAM

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C3=CCCCC3

InChI

InChIKey=IQWYAQCHYZHJOS-UHFFFAOYSA-N
InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

HIDE SMILES / InChI

Molecular Formula C16H17ClN2O
Molecular Weight 288.772
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tetrazepam was the most widely prescribed muscle relaxant in Germany. After a series of studies, which have shown, that tetrazepam caused cutaneous adverse effects and toxic epidermal necrolysis, the drug was withdrawn from the market.

Approval Year

PubMed

PubMed

TitleDatePubMed
Adverse reaction to tetrazepam.
2001
The usefulness of patch testing on the previously most severely affected site in a cutaneous adverse drug reaction to tetrazepam.
2001 Apr
Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions.
2001 Dec
Occupational contact allergy to tetrazepam.
2001 Jun
[Fatal toxic epidermal necrolysis associated with tetrazepam.
2001 Mar-Apr
Development of a novel parenteral formulation for tetrazepam using a lipid emulsion.
2001 Nov
[Analysis of benzodiazepine derivative mixture by gas-liquid chromatography].
2002
Formulating and stability of benzodiazepines in a new lipid emulsion formulation.
2002 Nov
Direct injection micellar liquid chromatographic determination of benzodiazepines in serum.
2002 Nov 25
Tetrazepam drug sensitivity -- usefulness of the patch test.
2002 Sep
[Determination of benzodiazepine derivatives mixture by high performance liquid chromatography].
2003
Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9.
2003 Jul
[Medical treatment of spasticity].
2003 May
Occupational airborne contact allergy to tetrazepam.
2003 Nov
Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
2004 Aug
Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig.
2004 Feb 25
[Drug Safety. Preventing medication errors].
2004 Jul-Aug
Medicinal and injection therapies for mechanical neck disorders.
2005 Apr 18
Screening and confirmatory method for benzodiazepines and hypnotics in oral fluid by LC-MS/MS.
2005 Jun 10
Occupational airborne contact dermatitis from sporadic exposure to tetrazepam during machine maintenance.
2005 Mar
Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes.
2005 Oct
Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry.
2005 Oct 15
Determination of ibuprofen and tetrazepam in human urine by micellar electrokinetic capillary chromatography.
2006 Jan
[Comparative study on Chinese medicine and western medicine for treatment of prolapse of lumbar intervertebral disc].
2007 May
Medicolegal aspects of tetrazepam metabolism.
2007 May
Occupational allergic contact dermatitis from tetrazepam in nurses.
2010 May
Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma.
2010 May
Patents

Sample Use Guides

Tetrazepam was given orally as a single dose of 50 mg and repeated administration for 5 consecutive days of 50 mg at 12-h intervals, in tablet form
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:58:21 UTC 2023
Edited
by admin
on Wed Jul 05 22:58:21 UTC 2023
Record UNII
FO92091VP8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TETRAZEPAM
EP   INN   MART.   MI   WHO-DD  
INN  
Official Name English
Tetrazepam [WHO-DD]
Common Name English
CB 4261
Code English
tetrazepam [INN]
Common Name English
TETRAZEPAM [EP MONOGRAPH]
Common Name English
TETRAZEPAM [MART.]
Common Name English
MYOLASTAN
Brand Name English
CB-4261
Code English
TETRAZEPAM [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QM03BX07
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
WHO-ATC M03BX07
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
DEA NO. 2886
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
NCI_THESAURUS C1012
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
Code System Code Type Description
INN
2182
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
SMS_ID
100000082738
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
DRUG CENTRAL
2614
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
ChEMBL
CHEMBL2105527
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
MERCK INDEX
M10661
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY Merck Index
FDA UNII
FO92091VP8
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
PUBCHEM
25215
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
DRUG BANK
DB13324
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
WIKIPEDIA
TETRAZEPAM
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
EVMPD
SUB10946MIG
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
CAS
10379-14-3
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
NCI_THESAURUS
C74282
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
EPA CompTox
DTXSID00146058
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
ECHA (EC/EINECS)
233-837-7
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
RXCUI
37985
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY RxNorm
MESH
C005245
Created by admin on Wed Jul 05 22:58:21 UTC 2023 , Edited by admin on Wed Jul 05 22:58:21 UTC 2023
PRIMARY
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