ISOPROPAMIDE CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H33N2O.Cl
Molecular Weight	388.974
Optical Activity	NONE
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)C(C)C

InChI

InChIKey=YDLRIMWTVADYID-UHFFFAOYSA-N

InChI=1S/C23H32N2O.ClH/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21;/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H33N2O
Molecular Weight	353.5209
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1

Isopropamide is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 162 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01005	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peptic ulcer 72 Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1	Primary		Approved 8583	DARBID Approved Use Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold. Launch Date 1957
Spasm 18 Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1	Primary		Approved 8583	DARBID Approved Use Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold. Launch Date 1957

Doses

Dose	Population	Adverse events
40 mg single, oral MTD Dose: 40 mg Route: oral Route: single Dose: 40 mg Sources: https://pubmed.ncbi.nlm.nih.gov/234981	unhealthy, 27-53 Health Status: unhealthy Age Group: 27-53 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/234981	Sources: https://pubmed.ncbi.nlm.nih.gov/234981

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY570133	https://www.001chemical.com/chem/7492-32-2
ABI Chem	AC1L1GON
Alfa Chemistry	7492-32-2
AstaTech	T72872
BOC Sciences	24353-18-2
BOC Sciences	71-81-8
BOC Sciences	7492-32-2
Chem Scene	CS-0013628
Chemieliva Pharmaceutical Co., Ltd	PBCM1405854
ChemMol	99052950	http://www.chemmol.com/chemmol/99052950.html
ChemTik	CTK4F3460
Compound Cloud	3775
Compound Cloud	6284
DC Chemicals	DC31720	http://www.dcchemicals.com//product_show-Isopropamide.html
eMolecules	1987293
eMolecules	4927826
eNovation Chemicals	D674430	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674430
Hairui	HR136820
mcule	MCULE-1763411393	https://mcule.com/MCULE-1763411393/
MedChem Express	HY-B1667
Molcore	MC570133	https://www.molcore.com/product/7492-32-2
MolPort	MolPort-003-666-211
MuseChem	I007382
MuseChem	M082189
MuseChem	R044777
NCI Plated 2007	15521
NCI Plated 2007	15548
NovoSeek	3775
Smolecule	S530944	http://www.smolecule.com/products/s530944
TargetMol	T5051
THE BioTek	bt-272350	https://www.thebiotek.com/product/inhibitors/bt-272350
TimTec	SBB058159
TimTec	ST51015028
ZINC	ZINC000001530668	http://zinc15.docking.org/substances/ZINC000001530668

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
2-Hydroxy-N,N'-diisopropylpropane-1,3-diaminium dichloride.	2010-06-23	21587980
Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.	2010-04	20376832
Simultaneous RP-HPLC Estimation of Trifluoperazine Hydrochloride and Chlordiazepoxide in Tablet Dosage Forms.	2009-09	20502574
Annotation of novel neuropeptide precursors in the migratory locust based on transcript screening of a public EST database and mass spectrometry.	2006-08-09	16899111
Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice.	2005-09-17	16168064
Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product.	2002-01-01	11682205
Spectrophotometric determination of trifluoperazine HCl and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods.	2001-09	11470197

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:55:09 GMT 2025` Edited by `admin` on `Mon Mar 31 22:55:09 GMT 2025`
Record UNII	F97R3WDS0Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZENEPROPANAMINIUM, .GAMMA.-(AMINOCARBONYL)-N-METHYL-N,N-BIS(1-METHYLETHYL)-.GAMMA.-PHENYL-, CHLORIDE (1:1)

Preferred Name

English

ISOPROPAMIDE CHLORIDE

Common Name

English

NSC-15548

Code

English

Code System Code Type Description

DRUG BANK

DBSALT002274