ISOPROPAMIDE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H33N2O
Molecular Weight	353.5209
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)C(C)C

InChI

InChIKey=JTPUMZTWMWIVPA-UHFFFAOYSA-O

InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1

HIDE SMILES / InChI

Molecular Formula	C23H33N2O
Molecular Weight	353.5209
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1

Isopropamide is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01005	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peptic ulcer 72 Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1	Primary		Approved 8429	DARBID Approved Use Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold. Launch Date 1957
Spasm 18 Sources: http://www.druginfosys.com/drug.aspx?drugcode=1301&type=1	Primary		Approved 8429	DARBID Approved Use Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold. Launch Date 1957

Doses

Dose	Population	Adverse events
40 mg single, oral (max) MTD Dose: 40 mg Route: oral Route: single Dose: 40 mg Sources: https://pubmed.ncbi.nlm.nih.gov/234981 Page: p.537	unhealthy, 27-53 n = 7 Health Status: unhealthy Condition: Duodenal ulcer Age Group: 27-53 Sex: M+F Population Size: 7 Sources: https://pubmed.ncbi.nlm.nih.gov/234981 Page: p.537	Sources: https://pubmed.ncbi.nlm.nih.gov/234981 Page: p.537

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY570133	https://www.001chemical.com/chem/7492-32-2
ABI Chem	AC1L1GON
Alfa Chemistry	7492-32-2
AstaTech	T72872
BOC Sciences	24353-18-2
BOC Sciences	71-81-8
BOC Sciences	7492-32-2
Chem Scene	CS-0013628
ChemMol	99052950	http://www.chemmol.com/chemmol/99052950.html
ChemTik	CTK4F3460
Chemieliva Pharmaceutical Co., Ltd	PBCM1405854
Compound Cloud	3775
Compound Cloud	6284
DC Chemicals	DC31720	http://www.dcchemicals.com//product_show-Isopropamide.html
Hairui	HR136820
MedChem Express	HY-B1667
MolPort	MolPort-003-666-211
Molcore	MC570133	https://www.molcore.com/product/7492-32-2
MuseChem	I007382
MuseChem	M082189
MuseChem	R044777
NCI Plated 2007	15521
NCI Plated 2007	15548
NovoSeek	3775
Smolecule	S530944	http://www.smolecule.com/products/s530944
THE BioTek	bt-272350	https://www.thebiotek.com/product/inhibitors/bt-272350
TargetMol	T5051
TimTec	SBB058159
TimTec	ST51015028
ZINC	ZINC000001530668	http://zinc15.docking.org/substances/ZINC000001530668
eMolecules	1987293
eMolecules	4927826
eNovation Chemicals	D674430	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674430
mcule	MCULE-1763411393	https://mcule.com/MCULE-1763411393/

PubMed

Title	Date	PubMed
Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.	2010 Apr	20376832
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443
2-Hydroxy-N,N'-diisopropylpropane-1,3-diaminium dichloride.	2010 Jun 23	21587980

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:43 GMT 2023` Edited by `admin` on `Fri Dec 15 16:14:43 GMT 2023`
Record UNII	8B9I31H724
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOPROPAMIDE

Common Name

English

ISOPROPAMIDE ION

Common Name

English

BENZENEPROPANAMINIUM, .GAMMA.-(AMINOCARBONYL)-N-METHYL-N,N-BIS(1-METHYLETHYL)-.GAMMA.-PHENYL-

Systematic Name

English

(3-CARBAMOYL-3,3-DIPHENYLPROPYL)DIISOPROPYLMETHYLAMMONIUM

Systematic Name

English

ISOPROPAMIDE CATION

Common Name

English

Isopropamide [WHO-DD]

Common Name

English

ISOPROPAMIDE [VANDF]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 520.1921