GSK-269962A

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H30N8O5
Molecular Weight	570.5991
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C(=NC2=C1C=C(OC3=CC(NC(=O)C4=CC=C(OCCN5CCOCC5)C=C4)=CC=C3)N=C2)C6=NON=C6N

InChI

InChIKey=YOVNFNXUCOWYSG-UHFFFAOYSA-N

InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38)

HIDE SMILES / InChI

Molecular Formula	C29H30N8O5
Molecular Weight	570.5991
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Rho-associated protein kinase 1 20 Target ID: Q13464 Gene ID: 6093.0 Gene Symbol: ROCK1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17018693	Inhibitor 8297		1.6 nM [IC50]
Rho-associated protein kinase 2 25 Target ID: O75116 Gene ID: 9475.0 Gene Symbol: ROCK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17018693	Inhibitor 8297		4.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:43:12 UTC 2023` Edited by `admin` on `Sat Dec 16 18:43:12 UTC 2023`
Record UNII	F89KMM7TE2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GSK-269962A

Common Name

English

GSK269962A

Code

English

N-(3-((2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-1H-IMIDAZO(4,5-C)PYRIDIN-6-YL)OXY)PHENYL)-4-(2-(4-MORPHOLINYL)ETHOXY)BENZAMIDE

Systematic Name

English

BENZAMIDE, N-(3-((2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-1H-IMIDAZO(4,5-C)PYRIDIN-6-YL)OXY)PHENYL)-4-(2-(4-MORPHOLINYL)ETHOXY)-

Systematic Name

English

GSK-269962

Code

English

GSK269962B

Code

English

Code System Code Type Description

CAS

850664-21-0

Created by admin on Sat Dec 16 18:43:12 UTC 2023 , Edited by admin on Sat Dec 16 18:43:12 UTC 2023

PRIMARY

IUPHAR

8037

Created by admin on Sat Dec 16 18:43:12 UTC 2023 , Edited by admin on Sat Dec 16 18:43:12 UTC 2023

PRIMARY

PUBCHEM

16095342

Created by admin on Sat Dec 16 18:43:12 UTC 2023 , Edited by admin on Sat Dec 16 18:43:12 UTC 2023

PRIMARY

FDA UNII

F89KMM7TE2

Created by admin on Sat Dec 16 18:43:12 UTC 2023 , Edited by admin on Sat Dec 16 18:43:12 UTC 2023

PRIMARY

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