Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H26N6O4S |
Molecular Weight | 506.577 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C(N)=NC(=N2)N3CCC4=C(C3)C=CC=C4NS(C)(=O)=O)C(C5=CC=CC=N5)=C1OC
InChI
InChIKey=OLYXPBZBZBVRGD-UHFFFAOYSA-N
InChI=1S/C25H26N6O4S/c1-34-20-13-19-22(21(23(20)35-2)18-8-4-5-11-27-18)24(26)29-25(28-19)31-12-10-16-15(14-31)7-6-9-17(16)30-36(3,32)33/h4-9,11,13,30H,10,12,14H2,1-3H3,(H2,26,28,29)
Molecular Formula | C25H26N6O4S |
Molecular Weight | 506.577 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/17932223
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17932223
Taprizosin (also known as UK-338,003) is an alpha1A-adrenoceptor antagonist that was developed for the treatment of benign prostatic hyperplasia. However, this compound possesses poor oral absorption.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists. | 2007 Aug |
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Investigation of regional mechanisms responsible for poor oral absorption in humans of a modified release preparation of the alpha-adrenoreceptor antagonist, 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): the rational use of ex vivo intestine to predict in vivo absorption. | 2008 Jan |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:42:22 GMT 2023
by
admin
on
Sat Dec 16 16:42:22 GMT 2023
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Record UNII |
EQ8YV2D86Y
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C29713
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NCI_THESAURUS |
C29707
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EQ8YV2D86Y
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DTXSID70175274
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210538-44-6
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CHEMBL401796
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6433102
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8286
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C66580
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300000034377
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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TRANSPORTER -> SUBSTRATE |
WEAK
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TARGET -> INHIBITOR |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Biological Half-life | PHARMACOKINETIC |
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ORAL ADMINISTRATION |
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Tmax | PHARMACOKINETIC |
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ORAL ADMINISTRATION |
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