ENERISANT

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H30N4O3
Molecular Weight	398.4986
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1CCCN1CCCOC2=CC=C(C=C2)N3C=C(C=N3)C(=O)N4CCOCC4

InChI

InChIKey=IABXVJILZYNSTM-GOSISDBHSA-N

InChI=1S/C22H30N4O3/c1-18-4-2-9-24(18)10-3-13-29-21-7-5-20(6-8-21)26-17-19(16-23-26)22(27)25-11-14-28-15-12-25/h5-8,16-18H,2-4,9-15H2,1H3/t18-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H30N4O3
Molecular Weight	398.4986
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://medkoo.com/products/6725 | https://www.who.int/medicines/services/inn/StemBook_2018.pdf

Enerisant is a histamine H3 receptor antagonist. In H3 receptor binding assay using (R)-α-methyl[3H]histamine, enerisant showed IC50 of 4.9 nM. Enerisant may be useful for the treatment of Alzheimer's disease, schizophrenia, etc.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 44 Target ID: CHEMBL264 Sources: https://medkoo.com/products/6725 \| https://www.who.int/medicines/services/inn/StemBook_2018.pdf	Antagonist 2778		4.9 nM [IC50]

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:42:48 UTC 2023` Edited by `admin` on `Sat Dec 16 09:42:48 UTC 2023`
Record UNII	E2Y97PQY3A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENERISANT

Official Name

English

METHANONE, (1-(4-(3-((2R)-2-METHYL-1-PYRROLIDINYL)PROPOXY)PHENYL)-1H-PYRAZOL-4-YL)-4-MORPHOLINYL-

Systematic Name

English

enerisant [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000037026