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Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 14:49:01 UTC 2023
Edited
by admin
on Sat Dec 16 14:49:01 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
D9SCP0G3HF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTAMINE H3 RECEPTOR
Common Name English
GPCR97
Common Name English
G-PROTEIN COUPLED RECEPTOR 97
Common Name English
H3R
Common Name English
HH3R
Common Name English
Code System Code Type Description
WIKIPEDIA
Histamine H3 receptor
Created by admin on Sat Dec 16 14:49:04 UTC 2023 , Edited by admin on Sat Dec 16 14:49:04 UTC 2023
PRIMARY
PHAROS
Q9Y5N1
Created by admin on Sat Dec 16 14:49:04 UTC 2023 , Edited by admin on Sat Dec 16 14:49:04 UTC 2023
PRIMARY
UNIPROT
Q9Y5N1
Created by admin on Sat Dec 16 14:49:04 UTC 2023 , Edited by admin on Sat Dec 16 14:49:04 UTC 2023
PRIMARY
FDA UNII
D9SCP0G3HF
Created by admin on Sat Dec 16 14:49:04 UTC 2023 , Edited by admin on Sat Dec 16 14:49:04 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_11
Related Record Type Details
Structure of MK-8278 C-11
INVERSE AGONIST->TARGET
Structure of IRDABISANT
INHIBITOR -> TARGET
Structure of CONESSINE
INHIBITOR -> TARGET
Structure of GSK-189254A
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of BAVISANT
INHIBITOR -> TARGET
Structure of IMMETHRIDINE
AGONIST -> TARGET
Structure of ABT-239
INVERSE AGONIST->TARGET
It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation
Structure of ENERISANT
INHIBITOR -> TARGET
Structure of CLOBENPROPIT
INHIBITOR -> TARGET
Structure of CIPRALISANT
LIGAND->TARGET
Structure of VUF-5681
INHIBITOR -> TARGET
Could have partial agonist activity. 3H-cAMP accumulation
IC50
Structure of MITAPIVAT
INHIBITOR->OFF-TARGET
BINDING ASSAY
IC50
Structure of LML-134
INVERSE AGONIST->TARGET
cAMP functional assay
Ki
Structure of PF-03654746
INHIBITOR -> TARGET
Structure of A-349821
INHIBITOR -> TARGET
Structure of CIPROXIFAN
INHIBITOR -> TARGET
Structure of PITOLISANT
INVERSE AGONIST->TARGET
Structure of SAMELISANT
INVERSE AGONIST->TARGET
Structure of MITAPIVAT
INVERSE AGONIST->TARGET
IC50
Structure of NERATINIB
INHIBITOR->OFF-TARGET
Structure of APD-916
INVERSE AGONIST->TARGET
Structure of THIOPERAMIDE
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
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