U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 20:22:42 UTC 2023
Edited
by admin
on Thu Jul 06 20:22:42 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
D9SCP0G3HF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTAMINE H3 RECEPTOR
Common Name English
GPCR97
Common Name English
G-PROTEIN COUPLED RECEPTOR 97
Common Name English
H3R
Common Name English
HH3R
Common Name English
Code System Code Type Description
WIKIPEDIA
Histamine H3 receptor
Created by admin on Thu Jul 06 20:22:44 UTC 2023 , Edited by admin on Thu Jul 06 20:22:44 UTC 2023
PRIMARY
PHAROS
Q9Y5N1
Created by admin on Thu Jul 06 20:22:44 UTC 2023 , Edited by admin on Thu Jul 06 20:22:44 UTC 2023
PRIMARY
UNIPROT
Q9Y5N1
Created by admin on Thu Jul 06 20:22:44 UTC 2023 , Edited by admin on Thu Jul 06 20:22:44 UTC 2023
PRIMARY
FDA UNII
D9SCP0G3HF
Created by admin on Thu Jul 06 20:22:44 UTC 2023 , Edited by admin on Thu Jul 06 20:22:44 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_11
Related Record Type Details
INHIBITOR -> TARGET
INVERSE AGONIST->TARGET
It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation
INVERSE AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
Could have partial agonist activity. 3H-cAMP accumulation
IC50
INHIBITOR->OFF-TARGET
BINDING ASSAY
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INVERSE AGONIST->TARGET
INVERSE AGONIST->TARGET
INVERSE AGONIST->TARGET
IC50
AGONIST -> TARGET
INHIBITOR->OFF-TARGET
INVERSE AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL