ENERISANT HYDROCHLORIDE DIHYDRATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H30N4O3.ClH.2H2O
Molecular Weight	470.99
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ENERISANT HYDROCHLORIDE DIHYDRATE

Structure Search

SMILES

O.O.Cl.C[C@@H]1CCCN1CCCOC2=CC=C(C=C2)N3C=C(C=N3)C(=O)N4CCOCC4

InChI

InChIKey=KAHPJCXENVTTHA-YTNSDAIYSA-N

InChI=1S/C22H30N4O3.ClH.2H2O/c1-18-4-2-9-24(18)10-3-13-29-21-7-5-20(6-8-21)26-17-19(16-23-26)22(27)25-11-14-28-15-12-25;;;/h5-8,16-18H,2-4,9-15H2,1H3;1H;2*1H2/t18-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula	C22H30N4O3
Molecular Weight	398.4986
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://medkoo.com/products/6725 | https://www.who.int/medicines/services/inn/StemBook_2018.pdf

Enerisant is a histamine H3 receptor antagonist. In H3 receptor binding assay using (R)-α-methyl[3H]histamine, enerisant showed IC50 of 4.9 nM. Enerisant may be useful for the treatment of Alzheimer's disease, schizophrenia, etc.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 46 Target ID: CHEMBL264 Sources: https://medkoo.com/products/6725 \| https://www.who.int/medicines/services/inn/StemBook_2018.pdf	Antagonist 2849		4.9 nM [IC50]

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:48:55 GMT 2025` Edited by `admin` on `Mon Mar 31 22:48:55 GMT 2025`
Record UNII	0W4IKH51WL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHANONE, (1-(4-(3-((2R)-2-METHYL-1-PYRROLIDINYL)PROPOXY)PHENYL)-1H-PYRAZOL-4-YL)-4-MORPHOLINYL-, HYDROCHLORIDE, HYDRATE (1:1:2)

Preferred Name

English

ENERISANT HYDROCHLORIDE DIHYDRATE

Common Name

English

Code System Code Type Description

CAS

1152749-09-1

Created by admin on Mon Mar 31 22:48:55 GMT 2025 , Edited by admin on Mon Mar 31 22:48:55 GMT 2025

PRIMARY

FDA UNII

0W4IKH51WL

Created by admin on Mon Mar 31 22:48:55 GMT 2025 , Edited by admin on Mon Mar 31 22:48:55 GMT 2025

PRIMARY

PUBCHEM

66933454

Created by admin on Mon Mar 31 22:48:55 GMT 2025 , Edited by admin on Mon Mar 31 22:48:55 GMT 2025

PRIMARY

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ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://medkoo.com/products/6725 | https://www.who.int/medicines/services/inn/StemBook_2018.pdf

Approval Year

Targets

Patents

Description
Sources: https://medkoo.com/products/6725 | https://www.who.int/medicines/services/inn/StemBook_2018.pdf