Dorocubicel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 14:13:03 GMT 2023` Edited by `admin` on `Sat Dec 16 14:13:03 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Development Stage	NEONATAL
Part Location	UMBILICAL CORD
Part	BLOOD
Fraction Name	CD34+ HSPC fraction
Record UNII	DBD2HM3I4V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Dorocubicel

Official Name

English

dorocubicel [INN]

Common Name

English

allogeneic human umbilical cord blood derived CD34+ hematopoietic stem and progenitor cells (HSPCs). The CD34+ HSPC fraction is selected from cord blood and expanded ex vivo in serum-free growth medium in the presence of UM171 (trans-N1 -[2-benzyl-7-(2-m

Common Name

English

CORD BLOOD EXPANDED WITH UM-171

Common Name

English

ALLOGENEIC HUMAN UMBILICAL CORD BLOOD EXPANDED WITH UM-171

Common Name

English

Classification Tree Code System Code

WHO-ATC

B05AX04

Created by admin on Sat Dec 16 14:13:03 GMT 2023 , Edited by admin on Sat Dec 16 14:13:03 GMT 2023

FDA ORPHAN DRUG

661418

Created by admin on Sat Dec 16 14:13:03 GMT 2023 , Edited by admin on Sat Dec 16 14:13:03 GMT 2023

Code System Code Type Description

INN

12158

Created by admin on Sat Dec 16 14:13:03 GMT 2023 , Edited by admin on Sat Dec 16 14:13:03 GMT 2023

PRIMARY

FDA UNII

DBD2HM3I4V

Created by admin on Sat Dec 16 14:13:03 GMT 2023 , Edited by admin on Sat Dec 16 14:13:03 GMT 2023

PRIMARY

Related Record Type Details


					DBD2HM3I4V

Dorocubicel

ACTIVE MOIETY

Comments:

stem cell transplantation

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-6	4O4QWG0B3C
CULTURE	ACTIVATOR	BIOLOGICAL	UM-171 DIHYDROBROMIDE DIHYDRATE	9VB5UBJ45H
CULTURE	EXPANSION	BIOLOGICAL	THROMBOPOIETIN	5651J3R2JF
CULTURE	EXPANSION	BIOLOGICAL	HUMAN SOLUBLE KIT LIGAND	ED35EH7CP2

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`ZWL6BH0E0S` HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34