Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H27N9.2BrH.2H2O |
| Molecular Weight | 651.397 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
| Stereo Comments | Substituted ring |
SHOW SMILES / InChI
SMILES
O.O.Br.Br.CN1N=NC(=N1)C2=CC3=C(C=C2)C4=C(N[C@H]5CC[C@H](N)CC5)N=C(CC6=CC=CC=C6)N=C4N3
InChI
InChIKey=LTZREELAANPAIQ-ZCPXLSQTSA-N
InChI=1S/C25H27N9.2BrH.2H2O/c1-34-32-23(31-33-34)16-7-12-19-20(14-16)28-25-22(19)24(27-18-10-8-17(26)9-11-18)29-21(30-25)13-15-5-3-2-4-6-15;;;;/h2-7,12,14,17-18H,8-11,13,26H2,1H3,(H2,27,28,29,30);2*1H;2*1H2/t17-,18-;;;;
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C25H27N9 |
| Molecular Weight | 453.5422 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.google.com/patents/WO2013110198A1 | https://www.ncbi.nlm.nih.gov/pubmed/28330619 | https://www.ncbi.nlm.nih.gov/pubmed/27337543 | https://clinicaltrials.gov/ct2/show/study/NCT02668315
Curator's Comment: description was created based on several sources, including
http://www.google.com/patents/WO2013110198A1 | https://www.ncbi.nlm.nih.gov/pubmed/28330619 | https://www.ncbi.nlm.nih.gov/pubmed/27337543 | https://clinicaltrials.gov/ct2/show/study/NCT02668315
UM171 is a potent agonist of human hematopoietic stem cell renewal, independently of AhR suppression. UM171 act differently than other small molecule stimulators of hematopoiesis, such as the aryl hydrocarbon receptor (AhR) antagonist StemRegenin 1 (SR1). Addition of UM171 to cultures containing SR1 and cytokines further enhances the ex vivo expansion of normal HSCs, including CD34+ cells.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: WP2849 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:24:57 GMT 2023
by
admin
on
Sat Dec 16 14:24:57 GMT 2023
|
| Record UNII |
9VB5UBJ45H
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
FDA ORPHAN DRUG |
661418
Created by
admin on Sat Dec 16 14:24:57 GMT 2023 , Edited by admin on Sat Dec 16 14:24:57 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
9VB5UBJ45H
Created by
admin on Sat Dec 16 14:24:57 GMT 2023 , Edited by admin on Sat Dec 16 14:24:57 GMT 2023
|
PRIMARY | |||
|
300000009940
Created by
admin on Sat Dec 16 14:24:57 GMT 2023 , Edited by admin on Sat Dec 16 14:24:57 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |