Fesomersen Sodium

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:35:26 UTC 2023` Edited by `admin` on `Sat Dec 16 15:35:26 UTC 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype	ANTI-SENSE
Sequence Type	COMPLETE
Record UNII	D8IRN5V2N6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Fesomersen Sodium

Official Name

English

FESOMERSEN SODIUM [USAN]

Common Name

English

DNA, d([2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-A-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-A-sp-m5C-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-

Common Name

English

ION-957943

Code

English

ION957943

Code

English

all-P-ambo-5'-O-(28-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis{[3-({6-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]hex-yl}amino)-3-oxopropoxy]methyl}-1-hydroxy-1,10,14,21-tetraoxo-2,18-dioxa-9,15,22-triaza-1λ5-phosphaoctacosan-1-yl)-2

Common Name

English

BAY2976217

Code

English

BAY-2976217

Code

English

Code System Code Type Description

NCI_THESAURUS

C190431

Created by admin on Sat Dec 16 15:35:26 UTC 2023 , Edited by admin on Sat Dec 16 15:35:26 UTC 2023

PRIMARY

USAN

KL-147

Created by admin on Sat Dec 16 15:35:26 UTC 2023 , Edited by admin on Sat Dec 16 15:35:26 UTC 2023

PRIMARY

FDA UNII

D8IRN5V2N6

Created by admin on Sat Dec 16 15:35:26 UTC 2023 , Edited by admin on Sat Dec 16 15:35:26 UTC 2023

PRIMARY

CAS

2380288-85-5

Created by admin on Sat Dec 16 15:35:26 UTC 2023 , Edited by admin on Sat Dec 16 15:35:26 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
	1_3-1_6;1_17-1_18	6 / 19
Sodium Phosporothioate	1_2;1_7-1_16;1_19-1_20	13 / 19

Related Record Type Details

0CF4C9C787

Fesomersen

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_2] [1_5]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION	[1_18] [1_19] [1_20]	SITE_SPECIFIC			THYMINE	QR26YLT7LT

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL