U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 15:26:50 UTC 2023
Edited
by admin
on Sat Dec 16 15:26:50 UTC 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype ANTI-SENSE
Sequence Type COMPLETE
Record UNII
0CF4C9C787
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Fesomersen
INN   USAN  
Official Name English
BAY-2976217 FREE ACID
Code English
BAY2976217 FREE ACID
Code English
BAY3563450
Code English
BAY-3563450
Code English
ION957943 FREE ACID
Code English
FESOMERSEN [USAN]
Common Name English
fesomersen [INN]
Common Name English
all-P-ambo-5'-O-(28-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis{[3-({6-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]hex-yl}amino)-3-oxopropoxy]methyl}-1-hydroxy-1,10,14,21-tetraoxo-2,18-dioxa-9,15,22-triaza-1λ5-phosphaoctacosan-1-yl)-2
Common Name English
ION-957943 FREE ACID
Code English
DNA, d([2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-A-sp-T-sp-T-sp-G-sp-G-sp-T-sp-G-sp-m5C-sp-A-sp-m5C-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-
Common Name English
Code System Code Type Description
USAN
KL-148
Created by admin on Sat Dec 16 15:26:50 UTC 2023 , Edited by admin on Sat Dec 16 15:26:50 UTC 2023
PRIMARY
FDA UNII
0CF4C9C787
Created by admin on Sat Dec 16 15:26:50 UTC 2023 , Edited by admin on Sat Dec 16 15:26:50 UTC 2023
PRIMARY
NCI_THESAURUS
C179086
Created by admin on Sat Dec 16 15:26:50 UTC 2023 , Edited by admin on Sat Dec 16 15:26:50 UTC 2023
PRIMARY
CAS
2380135-03-3
Created by admin on Sat Dec 16 15:26:50 UTC 2023 , Edited by admin on Sat Dec 16 15:26:50 UTC 2023
PRIMARY
INN
11638
Created by admin on Sat Dec 16 15:26:50 UTC 2023 , Edited by admin on Sat Dec 16 15:26:50 UTC 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Deoxyribose (DNA) 1_6-1_15 10 / 20
Linkage Site Range Site Count
Phosphate 1_3-1_6;1_17-1_18 6 / 19
Phosporothioate 1_2;1_7-1_16;1_19-1_20 13 / 19
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION [1_2] [1_5] SITE_SPECIFIC 5-METHYLCYTOSINE 6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION [1_18] [1_19] [1_20] SITE_SPECIFIC THYMINE QR26YLT7LT
NUCLEOTIDE SUBSTITUTION [1_1] 5'-TERMINUS UNSPECIFIED SUBSTANCE
6174f862
(not in database)