EBRONUCIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 07:49:36 GMT 2025` Edited by `admin` on `Wed Apr 02 07:49:36 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	CXX4Q31AAO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EBRONUCIMAB

Official Name

English

ebronucimab [INN]

Preferred Name

English

Ebronucimab [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G1-LAMBDA2, ANTI-(HOMO SAPIENS PCSK9 (PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC1, NARC-1, PROPROTEIN CONVERTASE 9, PC9)), HOMO SAPIENS MONOCLONAL ANTIBODY

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN NEURAL APOPTOSIS-REGULATED CONVERTASE 1) (HUMAN MONOCLONAL AK102 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AK102 .LAMBDA.-CHAIN, DIMER

Common Name

English

Code System Code Type Description

SMS_ID

300000028761

Created by admin on Wed Apr 02 07:49:36 GMT 2025 , Edited by admin on Wed Apr 02 07:49:36 GMT 2025

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INN

11476

Created by admin on Wed Apr 02 07:49:36 GMT 2025 , Edited by admin on Wed Apr 02 07:49:36 GMT 2025

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NCI_THESAURUS

C175774

Created by admin on Wed Apr 02 07:49:36 GMT 2025 , Edited by admin on Wed Apr 02 07:49:36 GMT 2025

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FDA UNII

CXX4Q31AAO

Created by admin on Wed Apr 02 07:49:36 GMT 2025 , Edited by admin on Wed Apr 02 07:49:36 GMT 2025

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CAS

2304800-90-4

Created by admin on Wed Apr 02 07:49:36 GMT 2025 , Edited by admin on Wed Apr 02 07:49:36 GMT 2025

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From	To
4_139	4_198
4_22	4_90
3_139	3_198
3_22	3_90
2_373	2_431
2_267	2_327
2_226	4_216
2_150	2_206
2_22	2_96
1_373	1_431
1_267	1_327
1_235	2_235
1_232	2_232
1_226	3_216
1_150	1_206
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details


					LGW95S5DG1

PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					CXX4Q31AAO

ACTIVE MOIETY

Comments:

Antihypercholesterolemic

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_453] [2_453]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL