TIMEPIDIUM

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H22NOS2
Molecular Weight	320.493
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

SMILES

COC1CC(C[N+](C)(C)C1)=C(C2=CC=CS2)C3=CC=CS3

InChI

InChIKey=PDYOTUCJOLELJU-UHFFFAOYSA-N

InChI=1S/C17H22NOS2/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16/h4-9,14H,10-12H2,1-3H3/q+1

HIDE SMILES / InChI

Molecular Formula	C17H22NOS2
Molecular Weight	320.493
Charge	1
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	( + / - )

Description

Timepidium bromide is a quaternary ammonium antimuscarinic used for the symptomatic treatment of visceral spasms. It is a muscarinic antagonist.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Muscarinic acetylcholine receptor M1 168	Antagonist 2,849	34.0 nM [Ki]
Muscarinic acetylcholine receptor M2 121	Antagonist 2,849	7.7 nM [Ki]
Muscarinic acetylcholine receptor M3 160	Antagonist 2,849	31.0 nM [Ki]
Muscarinic acetylcholine receptor M4 87	Antagonist 2,849	18.0 nM [Ki]
Muscarinic acetylcholine receptor M5 63	Antagonist 2,849	11.0 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Visceral spasms 6	Primary		Approved 8,583	Sesden

Doses

Show entries

Dose	Population	Adverse events
15 mg single, intravenous Highest studied dose	unhealthy, ADULT
30 mg 3 times / day multiple, oral Recommended	unhealthy, ADULT	Disc. AE: Eosinophilic pustular folliculitis...

Showing 1 to 2 of 2 entries

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AEs

Show entries

AE	Significance	Dose	Population
Eosinophilic pustular folliculitis	Disc. AE	30 mg 3 times / day multiple, oral Recommended	unhealthy, ADULT

Showing 1 to 1 of 1 entries

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PubMed

Title	Date	PubMed
No data available in table

Patents

Sample Use Guides

In Vivo Use Guide

Adult Dosage: 30mg x 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

Timepidium inhibited dose-dependently the contraction of isolated guinea pig gallbladder evoked by stimulation at 5 Hz. The mean dose producing a 50 % decrease in the electrically induced contraction (ID50 value) was 2.4 x 10(-8) g/ml. Timepidium (10(-6) g/ml) also inhibited, for the most part, the contraction induced by stimulation at 30 Hz.