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Details

Stereochemistry RACEMIC
Molecular Formula C17H22NOS2.Cl
Molecular Weight 355.946
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIMEPIDIUM CHLORIDE

SMILES

[Cl-].COC1CC(C[N+](C)(C)C1)=C(C2=CC=CS2)C3=CC=CS3

InChI

InChIKey=QKMGSNFPZNTQHE-UHFFFAOYSA-M
InChI=1S/C17H22NOS2.ClH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C17H22NOS2
Molecular Weight 320.493
Charge 1
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Timepidium bromide is a quaternary ammonium antimuscarinic used for the symptomatic treatment of visceral spasms. It is a muscarinic antagonist.

CNS Activity

CNS Non-penetrant
1014
Curator's Comment: Timepidium does not cross the blood–brain barrier

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 34.0 nM [Ki]
Antagonist
2778
 7.7 nM [Ki]
Antagonist
2778
 31.0 nM [Ki]
Antagonist
2778
 18.0 nM [Ki]
Antagonist
2778
 11.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Sesden

Approved Use

Visceral spasms
PubMed

PubMed

TitleDatePubMed
Eosinophilic pustular folliculitis induced by allopurinol and timepidium bromide.
2002
Multiple granulomatous inflammation in the minor salivary glands: a proposed new entity, allergic granulomatous sialadenitis.
2004 Nov
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Patents

US20030068365
9
US6638528
14

Sample Use Guides

In Vivo Use Guide
Adult Dosage: 30mg x 3 times a day.
Route of Administration: Oral
In Vitro Use Guide
Timepidium inhibited dose-dependently the contraction of isolated guinea pig gallbladder evoked by stimulation at 5 Hz. The mean dose producing a 50 % decrease in the electrically induced contraction (ID50 value) was 2.4 x 10(-8) g/ml. Timepidium (10(-6) g/ml) also inhibited, for the most part, the contraction induced by stimulation at 30 Hz.
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:45:07 UTC 2023
Edited
by admin
on Sat Dec 16 11:45:07 UTC 2023
Record UNII
W5689X6OZE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIMEPIDIUM CHLORIDE
Common Name English
PIPERIDINIUM, 3-(DI-2-THIENYLMETHYLENE)-5-METHOXY-1,1-DIMETHYL-, CHLORIDE
Systematic Name English
PIPERIDINIUM, 3-(DI-2-THIENYLMETHYLENE)-5-METHOXY-1,1-DIMETHYL-, CHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
13604123
Created by admin on Sat Dec 16 11:45:07 UTC 2023 , Edited by admin on Sat Dec 16 11:45:07 UTC 2023
PRIMARY
FDA UNII
W5689X6OZE
Created by admin on Sat Dec 16 11:45:07 UTC 2023 , Edited by admin on Sat Dec 16 11:45:07 UTC 2023
PRIMARY
CAS
100595-66-2
Created by admin on Sat Dec 16 11:45:07 UTC 2023 , Edited by admin on Sat Dec 16 11:45:07 UTC 2023
PRIMARY
Related Record Type Details
Structure of TIMEPIDIUM CHLORIDE, (R)-
ENANTIOMER -> RACEMATE
Structure of TIMEPIDIUM CHLORIDE, (S)-
ENANTIOMER -> RACEMATE
Structure of TIMEPIDIUM
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of TIMEPIDIUM
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